Enhanced antimicrobial properties, cytocompatibility, and corrosion resistance of plasma-modified biodegradable magnesium alloys

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Ying Zhao
  • Mohammed Ibrahim Jamesh
  • Wing Kan Li
  • Guosong Wu
  • Chenxi Wang
  • Yufeng Zheng
  • Kelvin W.K. Yeung

Detail(s)

Original languageEnglish
Pages (from-to)544-556
Journal / PublicationActa Biomaterialia
Volume10
Issue number1
Online published18 Oct 2013
Publication statusPublished - Jan 2014

Abstract

Magnesium alloys are potential biodegradable materials and have received increasing attention due to their outstanding biological performance and mechanical properties. However, rapid degradation in the physiological environment and potential toxicity limit clinical applications. Recently, special magnesium-calcium (Mg-Ca) and magnesium-strontium (Mg-Sr) alloys with biocompatible chemical compositions have been reported, but the rapid degradation still does not meet clinical requirements. In order to improve the corrosion resistance, a rough, hydrophobic and ZrO2-containing surface film is fabricated on Mg-Ca and Mg-Sr alloys by dual zirconium and oxygen ion implantation. Weight loss measurements and electrochemical corrosion tests show that the corrosion rate of the Mg-Ca and Mg-Sr alloys is reduced appreciably after surface treatment. A systematic investigation of the in vitro cellular response and antibacterial capability of the modified binary magnesium alloys is performed. The amounts of adherent bacteria on the Zr-O-implanted and Zr-implanted samples diminish remarkably compared to the unimplanted control. In addition, significantly enhanced cell adhesion and proliferation are observed from the Zr-O-implanted sample. The results suggest that dual zirconium and oxygen ion implantation, which effectively enhances the corrosion resistance, in vitro biocompatibility and antimicrobial properties of Mg-Ca and Mg-Sr alloys, provides a simple and practical means to expedite clinical acceptance of biodegradable magnesium alloys. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Research Area(s)

  • Biodegradable, Corrosion, Cytocompatibility, Interfaces, Magnesium alloy

Citation Format(s)

Enhanced antimicrobial properties, cytocompatibility, and corrosion resistance of plasma-modified biodegradable magnesium alloys. / Zhao, Ying; Jamesh, Mohammed Ibrahim; Li, Wing Kan et al.
In: Acta Biomaterialia, Vol. 10, No. 1, 01.2014, p. 544-556.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review