Engineering embolic microparticles from a periodically-pulsating charged liquid meniscus

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

4 Scopus Citations
View graph of relations

Author(s)

  • Xiaowei Tian
  • Tiantian Kong
  • Zhanxiao Kang
  • Leyan Lei
  • Xin Tang
  • Liqiu Wang

Detail(s)

Original languageEnglish
Pages (from-to)13-19
Journal / PublicationChemical Engineering Science
Volume183
Online published26 Feb 2018
Publication statusPublished - 29 Jun 2018
Externally publishedYes

Abstract

A commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number BE being from 0.3 to 1 and Weber number We < 1, where the conical tip of the charged meniscus emits a single yet fine droplet periodically. The droplet diameter dd and its generation frequency f scale with the dimensionless controlling parameters in the form of d∼ q0.5, ∼ q-0.15BE0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties.

Research Area(s)

  • Electrospray, Embolic microparticles, Micro-dripping mode, Pulsating meniscus

Citation Format(s)

Engineering embolic microparticles from a periodically-pulsating charged liquid meniscus. / Tian, Xiaowei; Kong, Tiantian; Zhu, Pingan et al.
In: Chemical Engineering Science, Vol. 183, 29.06.2018, p. 13-19.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review