Endowing AIE with Extraordinary Potential : A New Au(I)-Containing AIEgen for Bimodal Bioimaging-Guided Multimodal Synergistic Cancer Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jing Zhang
  • Hang Zou
  • Benzhao He
  • Chen Peng
  • Jacky W. Y. Lam
  • Lei Zheng
  • Ben Zhong Tang

Detail(s)

Original languageEnglish
Article number2108199
Journal / PublicationAdvanced Functional Materials
Publication statusOnline published - 5 Oct 2021

Abstract

The development of high-performance theranostic platforms is always an intractable challenge in modern medicine research. Herein, new luminescent materials that possess the advantages of high sensitivity, high resolution, and deep tumor-penetrating imaging as well as multimodal synergistic therapeutic functions may be one of the best potential alternatives for efficient theranostics. In this work, a powerful Au(I)-containing aggregation-induce emission luminogen (AIEgen) with integrated multifunctions of bimodal imaging and multimodal combination therapy is developed. This simple small-molecule system can simultaneously realize high-contrast fluorescence imaging and computed tomography imaging. Additionally, it can act as an effective thioredoxin reductase inhibitor to exert inherent anticancer effect, and simultaneously work as an ideal radiosensitizer to produce efficient anticancer efficacy through a multimodal synergistic effect. Thus, this study highlights a new design guideline to endow AIE luminogens with extraordinary functions by Au(I) and opens a new avenue for the development of new luminescent theranostic systems.

Research Area(s)

  • aggregation-induced emission, bimodal bioimaging, gold(I) complex, multimodal synergistic therapy, GOLD NANOPARTICLES, COMPLEXES, OXIDATION

Citation Format(s)

Endowing AIE with Extraordinary Potential : A New Au(I)-Containing AIEgen for Bimodal Bioimaging-Guided Multimodal Synergistic Cancer Therapy. / Zhang, Jing; Zou, Hang; Gan, Shifeng; He, Benzhao; Huang, Jacob C.; Peng, Chen; Lam, Jacky W. Y.; Zheng, Lei; Tang, Ben Zhong.

In: Advanced Functional Materials, 05.10.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review