Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models

Wei Hu; Hongling Liu; Hong Sun; Ouxi Shen; Xinru Wang; Michael H.W. Lam; John P. Giesy; Xiaowei Zhang; Hongxia Yu

doi:10.1016/j.marpolbul.2011.08.037

Author(s)

Wei Hu
Hongling Liu
Hong Sun
Ouxi Shen
Xinru Wang
And 4 others

Michael H.W. Lam
John P. Giesy
Xiaowei Zhang
Hongxia Yu

Detail(s)

Original language	English
Pages (from-to)	2356-2361
Journal / Publication	Marine Pollution Bulletin
Volume	62
Issue number	11
Publication status	Published - Nov 2011

Link(s)

DOI	DOI https://doi.org/10.1016/j.marpolbul.2011.08.037 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-82455198560&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(38162edd-aeba-4b14-9345-d8dcd11a1ac9).html

Abstract

Methoxylated brominated diphenyl ethers (MeO-BDEs) in aquatic environments have been found to be primarily of natural origin in the marine environment and not from biotransformation of synthetic PBDEs. Two of the eight MeO-PBDEs (2'-MeO-BDE-68 and 6-MeO-BDE-47) that were detected in anchovy from the Yangtze River Delta, were natural products from marine organisms. So 2'-MeO-BDE-68 and 6-MeO-BDE-47 were chosen to study the potential to modulate androgen, estrogen, or thyroid hormone receptor- (AR, ER, ThR) mediated responses by use of reporter gene assays. 2'-MeO-BDE-68 was antiandrogenic at 50μM, estrogenic at 10μM and antiestrogenic at 10 and 50μM (IC ₅₀=4.88μM). 2'-MeO-BDE-68 enhanced luciferase expression by 5nM T3 at 50μM. 6-MeO-BDE-47 exhibited potent antiandrogenicity at 1μM and greater (IC ₅₀=41.8μM) and possessed estrogenic activity at 10μM and antiestrogenic activity at 10 and 50μM (IC ₅₀=6.02μM). © 2011 Elsevier Ltd.

Research Area(s)

2'-MeO-BDE-68, 6-MeO-BDE-47, Androgen receptor, Estrogen receptor, Receptor-mediated pathway, Reporter gene assay, Thyroid receptor

Citation Format(s)

[ RIS ] [ BibTeX ]

Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. / Hu, Wei; Liu, Hongling; Sun, Hong et al.
In: Marine Pollution Bulletin, Vol. 62, No. 11, 11.2011, p. 2356-2361.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Hu, W, Liu, H, Sun, H, Shen, O, Wang, X, Lam, MHW, Giesy, JP, Zhang, X & Yu, H 2011, 'Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models', Marine Pollution Bulletin, vol. 62, no. 11, pp. 2356-2361. https://doi.org/10.1016/j.marpolbul.2011.08.037

Hu, W., Liu, H., Sun, H., Shen, O., Wang, X., Lam, M. H. W., Giesy, J. P., Zhang, X., & Yu, H. (2011). Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. Marine Pollution Bulletin, 62(11), 2356-2361. https://doi.org/10.1016/j.marpolbul.2011.08.037

Hu W, Liu H, Sun H, Shen O, Wang X, Lam MHW et al. Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. Marine Pollution Bulletin. 2011 Nov;62(11):2356-2361. doi: 10.1016/j.marpolbul.2011.08.037

Hu, Wei ; Liu, Hongling ; Sun, Hong et al. / Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. In: Marine Pollution Bulletin. 2011 ; Vol. 62, No. 11. pp. 2356-2361.