Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Michael H.W. Lam
  • John P. Giesy
  • Xiaowei Zhang
  • Hongxia Yu

Detail(s)

Original languageEnglish
Pages (from-to)2356-2361
Journal / PublicationMarine Pollution Bulletin
Volume62
Issue number11
Publication statusPublished - Nov 2011

Abstract

Methoxylated brominated diphenyl ethers (MeO-BDEs) in aquatic environments have been found to be primarily of natural origin in the marine environment and not from biotransformation of synthetic PBDEs. Two of the eight MeO-PBDEs (2'-MeO-BDE-68 and 6-MeO-BDE-47) that were detected in anchovy from the Yangtze River Delta, were natural products from marine organisms. So 2'-MeO-BDE-68 and 6-MeO-BDE-47 were chosen to study the potential to modulate androgen, estrogen, or thyroid hormone receptor- (AR, ER, ThR) mediated responses by use of reporter gene assays. 2'-MeO-BDE-68 was antiandrogenic at 50μM, estrogenic at 10μM and antiestrogenic at 10 and 50μM (IC 50=4.88μM). 2'-MeO-BDE-68 enhanced luciferase expression by 5nM T3 at 50μM. 6-MeO-BDE-47 exhibited potent antiandrogenicity at 1μM and greater (IC 50=41.8μM) and possessed estrogenic activity at 10μM and antiestrogenic activity at 10 and 50μM (IC 50=6.02μM). © 2011 Elsevier Ltd.

Research Area(s)

  • 2'-MeO-BDE-68, 6-MeO-BDE-47, Androgen receptor, Estrogen receptor, Receptor-mediated pathway, Reporter gene assay, Thyroid receptor

Citation Format(s)

Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. / Hu, Wei; Liu, Hongling; Sun, Hong; Shen, Ouxi; Wang, Xinru; Lam, Michael H.W.; Giesy, John P.; Zhang, Xiaowei; Yu, Hongxia.

In: Marine Pollution Bulletin, Vol. 62, No. 11, 11.2011, p. 2356-2361.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review