Encapsulating pH-Responsive Doxorubicin–Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

23 Scopus Citations
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Author(s)

  • Roy C. H. Wong
  • Dennis K. P. Ng
  • Wing-Ping Fong
  • Pui-Chi Lo

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)16505-16515
Journal / PublicationChemistry - A European Journal
Volume23
Issue number65
Online published19 Sep 2017
Publication statusPublished - 21 Nov 2017

Abstract

Doxorubicin (Dox) was conjugated to a zinc(II) phthalocyanine (ZnPc) through an acid-cleavable hydrazone linker. This azido-containing conjugate was then anchored to the nanochannels of an alkyne-modified mesoporous silica nanoparticle (MSN) system via copper(I)-catalyzed azide–alkyne cycloaddition. An analogous nanosystem was also prepared by immobilization of a hydrazine-substituted ZnPc to the MSN followed by coupling with Dox. The release of Dox under acidic conditions was studied in phosphate-buffered saline. After internalization into human hepatocellular carcinoma HepG2 cells, these nanoparticles showed fluorescence not only for ZnPc, but also for Dox, suggesting that release of Dox was triggered by the acidic intracellular environment. The chemocytotoxic Dox together with singlet oxygen generated upon irradiation on the encapsulated ZnPc in these MSNs could kill the cells effectively. A synergistic cytotoxicity was suggested by a less-than-unity combination index. These nanoparticles function as both nanophotosensitizers for photodynamic therapy and as nanoplatforms for pH-controlled drug release.

Research Area(s)

  • chemotherapy, doxorubicin, mesoporous silica nanoparticles, photodynamic therapy, phthalocyanines

Citation Format(s)

Encapsulating pH-Responsive Doxorubicin–Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy. / Wong, Roy C. H.; Ng, Dennis K. P.; Fong, Wing-Ping; Lo, Pui-Chi.

In: Chemistry - A European Journal, Vol. 23, No. 65, 21.11.2017, p. 16505-16515.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal