Enantioselective Alkylation of Glycine Imine Promoted by Amino-Acid-Derived Phosphonium Salts

Shan Wen; Xing Li; Yixin Lu

doi:10.1002/ajoc.201600394

Enantioselective Alkylation of Glycine Imine Promoted by Amino-Acid-Derived Phosphonium Salts

Shan Wen, Xing Li, Yixin Lu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

36 Citations (Scopus)

Abstract

Chiral phosphonium salts derived from natural amino acids were prepared and applied to the asymmetric alkylation reaction of glycine imine with substituted benzyl bromides, and the desired alkylation products were obtained in high yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Original language	English
Pages (from-to)	1457-1460
Journal	Asian Journal of Organic Chemistry
Volume	5
Issue number	12
DOIs	https://doi.org/10.1002/ajoc.201600394
Publication status	Published - 1 Dec 2016
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

alkylation
amino acids
asymmetric catalysis
phase-transfer catalysis
phosphonium salts

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title = "Enantioselective Alkylation of Glycine Imine Promoted by Amino-Acid-Derived Phosphonium Salts",

abstract = "Chiral phosphonium salts derived from natural amino acids were prepared and applied to the asymmetric alkylation reaction of glycine imine with substituted benzyl bromides, and the desired alkylation products were obtained in high yields and with excellent enantioselectivities. {\textcopyright} 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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author = "Shan Wen and Xing Li and Yixin Lu",

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doi = "10.1002/ajoc.201600394",

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T1 - Enantioselective Alkylation of Glycine Imine Promoted by Amino-Acid-Derived Phosphonium Salts

AU - Wen, Shan

AU - Li, Xing

AU - Lu, Yixin

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Chiral phosphonium salts derived from natural amino acids were prepared and applied to the asymmetric alkylation reaction of glycine imine with substituted benzyl bromides, and the desired alkylation products were obtained in high yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

AB - Chiral phosphonium salts derived from natural amino acids were prepared and applied to the asymmetric alkylation reaction of glycine imine with substituted benzyl bromides, and the desired alkylation products were obtained in high yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

KW - alkylation

KW - amino acids

KW - asymmetric catalysis

KW - phase-transfer catalysis

KW - phosphonium salts

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U2 - 10.1002/ajoc.201600394

DO - 10.1002/ajoc.201600394

M3 - RGC 21 - Publication in refereed journal

SN - 2193-5807

VL - 5

SP - 1457

EP - 1460

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 12

ER -

Enantioselective Alkylation of Glycine Imine Promoted by Amino-Acid-Derived Phosphonium Salts

Abstract

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Research Keywords

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