Abstract
Aqueous two-phase systems (ATPSs) have been recognized for their applications in extraction, separation, purification, and enrichment of (bio)molecules and cells. Recently, their unique ability to create aqueous-aqueous interfaces through phase separation and the characteristics of these interfaces have created new opportunities in biomedical applications. In this review, we summarize recent progress in understanding the dynamics at aqueous-aqueous interfaces, and in developing interface-assisted design of artificial cells and cyto-mimetic materials, fabrication of cyto- A nd bio-compatible microparticles, cell micropatterning, 3D bioprinting, and microfluidic separation of cells and biomolecules. We also discuss the challenges and perspectives to leverage the unique characteristics of ATPSs and their interfaces in broader applications. © The Royal Society of Chemistry 2020.
| Original language | English |
|---|---|
| Pages (from-to) | 114-142 |
| Journal | Chemical Society Reviews |
| Volume | 49 |
| Issue number | 1 |
| Online published | 21 Nov 2019 |
| DOIs | |
| Publication status | Published - 7 Jan 2020 |
| Externally published | Yes |
Funding
This research was supported by the General Research Fund (No. 17306315, 17329516, 17304017, 17304418, and 17307919), the Collaborative Research Fund (C6004-14G) from the Research Grants Council of Hong Kong, the Seed Funding Programme for Basic Research (No. 201811159241, and 201711159249) and the Seed Funding for Strategic Interdisciplinary Research Scheme from the University of Hong Kong, as well as the Sichuan Science and Technology Program (2018JZ0026).
RGC Funding Information
- RGC-funded
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