Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

18 Scopus Citations
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Author(s)

  • Lingbin Shu
  • Ning Dong
  • Jun Lu
  • Zhiwei Zheng
  • Jie Hu
  • Wenqing Zeng
  • Qiaoling Sun
  • Edward Wai-Chi Chan
  • Hongwei Zhou
  • Fupin Hu
  • Rong Zhang

Detail(s)

Original languageEnglish
Article numbere02246-18
Journal / PublicationAntimicrobial Agents and Chemotherapy
Volume63
Issue number3
Online published26 Feb 2019
Publication statusPublished - Mar 2019
Externally publishedYes

Abstract

This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The blaOXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.

Research Area(s)

  • Clonal spread, Klebsiella pneumoniae, OXA-232, Virulence plasmid, Virulence potential

Citation Format(s)

Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China. / Shu, Lingbin; Dong, Ning; Lu, Jun; Zheng, Zhiwei; Hu, Jie; Zeng, Wenqing; Sun, Qiaoling; Chan, Edward Wai-Chi; Zhou, Hongwei; Hu, Fupin; Chen, Sheng; Zhang, Rong.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 3, e02246-18, 03.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal