Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

Lingbin Shu; Ning Dong; Jun Lu; Zhiwei Zheng; Jie Hu; Wenqing Zeng; Qiaoling Sun; Edward Wai-Chi Chan; Hongwei Zhou; Fupin Hu; Sheng Chen; Rong Zhang

doi:10.1128/AAC.02246-18

Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

Lingbin Shu
, Ning Dong
, Jun Lu
, Zhiwei Zheng
, Jie Hu
, Wenqing Zeng
, Qiaoling Sun
, Edward Wai-Chi Chan
, Hongwei Zhou
, Fupin Hu
, Sheng Chen^*
, Rong Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

78 Citations (Scopus)

Abstract

This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The bla_OXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.

Original language	English
Article number	e02246-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	3
Online published	26 Feb 2019
DOIs	https://doi.org/10.1128/AAC.02246-18
Publication status	Published - Mar 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Clonal spread
Klebsiella pneumoniae
OXA-232
Virulence plasmid
Virulence potential

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10.1128/AAC.02246-18

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Shu, L., Dong, N., Lu, J., Zheng, Z., Hu, J., Zeng, W., Sun, Q., Chan, E. W.-C., Zhou, H., Hu, F., Chen, S., & Zhang, R. (2019). Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China. Antimicrobial Agents and Chemotherapy, 63(3), Article e02246-18. https://doi.org/10.1128/AAC.02246-18

@article{b977d65dcc5f4d91871de7f041d4c3db,

title = "Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China",

abstract = "This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The blaOXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.",

keywords = "Clonal spread, Klebsiella pneumoniae, OXA-232, Virulence plasmid, Virulence potential",

author = "Lingbin Shu and Ning Dong and Jun Lu and Zhiwei Zheng and Jie Hu and Wenqing Zeng and Qiaoling Sun and Chan, \{Edward Wai-Chi\} and Hongwei Zhou and Fupin Hu and Sheng Chen and Rong Zhang",

year = "2019",

month = mar,

doi = "10.1128/AAC.02246-18",

language = "English",

volume = "63",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "3",

}

Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China. / Shu, Lingbin; Dong, Ning; Lu, Jun et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 3, e02246-18, 03.2019.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

AU - Shu, Lingbin

AU - Dong, Ning

AU - Lu, Jun

AU - Zheng, Zhiwei

AU - Hu, Jie

AU - Zeng, Wenqing

AU - Sun, Qiaoling

AU - Chan, Edward Wai-Chi

AU - Zhou, Hongwei

AU - Hu, Fupin

AU - Chen, Sheng

AU - Zhang, Rong

PY - 2019/3

Y1 - 2019/3

N2 - This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The blaOXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.

AB - This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The blaOXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.

KW - Clonal spread

KW - Klebsiella pneumoniae

KW - OXA-232

KW - Virulence plasmid

KW - Virulence potential

UR - https://www.scopus.com/pages/publications/85062267289

UR - https://www.scopus.com/pages/publications/85062267289#tab=impact

U2 - 10.1128/AAC.02246-18

DO - 10.1128/AAC.02246-18

M3 - RGC 21 - Publication in refereed journal

C2 - 30559135

SN - 0066-4804

VL - 63

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

M1 - e02246-18

ER -

Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

Abstract

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