Emergence of conjugative IncC type plasmid simultaneously encoding resistance to ciprofloxacin, ceftriaxone and azithromycin in Salmonella

Non-typical Salmonella is a primary cause of food-borne diseases and considered as a major public health concern worldwide (1, 2). The current choices of treatment for systemic Salmonella infections are ciprofloxacin, ceftriaxone, and azithromycin (3). Clinical Salmonella isolates resistant to these three antibiotics have been detected occasionally in recent years, but cotransfer of such three antimicrobial resistance determinants in one plasmid was rarely reported (4).