Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

Paweł M Bęczkowski; Navapon Techakriengkrai; Nicola Logan; Elizabeth McMonagle; Annette Litster; Brian J Willett; Margaret J Hosie

doi:10.1186/s12977-014-0095-7

Author(s)

Navapon Techakriengkrai
Nicola Logan
Elizabeth McMonagle
Annette Litster
Brian J Willett
Margaret J Hosie

Detail(s)

Original language	English
Article number	95
Journal / Publication	Retrovirology
Volume	11
Issue number	1
Publication status	Published - 28 Nov 2014
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1186/s12977-014-0095-7 Final Published version
	Check@CityULib
Attachment(s)	Documents 84493029.pdf Final Published version, 381 KB, PDF Publisher's Copyright Statement This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84934941139&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(c994d2a8-8bd7-4200-999d-7d2c759ad2e9).html

Abstract

Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.

Research Area(s)

CD134, CRD2, Disease progression, Evolution, FIV, Natural infection, OX40, Receptor

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.