Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

Paweł M Bęczkowski; Navapon Techakriengkrai; Nicola Logan; Elizabeth McMonagle; Annette Litster; Brian J Willett; Margaret J Hosie

doi:10.1186/s12977-014-0095-7

Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

Paweł M Bęczkowski
, Navapon Techakriengkrai
, Nicola Logan
, Elizabeth McMonagle
, Annette Litster
, Brian J Willett
, Margaret J Hosie^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

44 Downloads (CityUHK Scholars)

Abstract

Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.

Original language	English
Article number	95
Journal	Retrovirology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s12977-014-0095-7
Publication status	Published - 28 Nov 2014
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

CD134
CRD2
Disease progression
Evolution
FIV
Natural infection
OX40
Receptor

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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title = "Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats",

abstract = "Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.",

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Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats. / Bęczkowski, Paweł M; Techakriengkrai, Navapon; Logan, Nicola et al.
In: Retrovirology, Vol. 11, No. 1, 95, 28.11.2014.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

AU - Bęczkowski, Paweł M

AU - Techakriengkrai, Navapon

AU - Logan, Nicola

AU - McMonagle, Elizabeth

AU - Litster, Annette

AU - Willett, Brian J

AU - Hosie, Margaret J

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2014/11/28

Y1 - 2014/11/28

N2 - Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.

AB - Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.

KW - CD134

KW - CRD2

KW - Disease progression

KW - Evolution

KW - FIV

KW - Natural infection

KW - OX40

KW - Receptor

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U2 - 10.1186/s12977-014-0095-7

DO - 10.1186/s12977-014-0095-7

M3 - RGC 21 - Publication in refereed journal

C2 - 25430586

SN - 1742-4690

VL - 11

JO - Retrovirology

JF - Retrovirology

IS - 1

M1 - 95

ER -

Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

Abstract

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Research Keywords

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