Brachyspira aalborgi infection in four Australian children

RALF G HEINE; PETER B WARD; ANDREW SJ MIKOSZA; VICKI BENNETT-WOOD; ROY M ROBINS-BROWNE; DAVID J HAMPSON

doi:10.1046/j.1440-1746.2001.t01-1-02543.x

Brachyspira aalborgi infection in four Australian children

RALF G HEINE, PETER B WARD, ANDREW SJ MIKOSZA, VICKI BENNETT-WOOD, ROY M ROBINS-BROWNE, DAVID J HAMPSON

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

25 Citations (Scopus)

Abstract

Aim: The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9–16 years) with colorectal spirochetosis is discussed.

Results: Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal spirochetosis was an unanticipated finding on colonic histology, and the presence of spirochetes was confirmed by the use of electron microscopy. Spirochetes were identified as Brachyspira aalborgi by using PCR amplification of the bacterial 16S rRNA and nicotinamide adenine dinucleotide oxidase sequences in all four patients. No other enteric pathogens were found.

Conclusions: Although all patients appeared to respond to antibiotic treatment, the clinical significance of B. aalborgi as a human pathogen requires further investigation.

Original language	English
Pages (from-to)	872-875
Journal	Journal of Gastroenterology and Hepatology (Australia)
Volume	16
Issue number	8
DOIs	https://doi.org/10.1046/j.1440-1746.2001.t01-1-02543.x
Publication status	Published - Aug 2001
Externally published	Yes

Research Keywords

Abdominal pain
Brachyspira
Colon
Diarrhea
Spirochetosis

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title = "Brachyspira aalborgi infection in four Australian children",

abstract = "Aim: The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9–16 years) with colorectal spirochetosis is discussed.Results: Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal spirochetosis was an unanticipated finding on colonic histology, and the presence of spirochetes was confirmed by the use of electron microscopy. Spirochetes were identified as Brachyspira aalborgi by using PCR amplification of the bacterial 16S rRNA and nicotinamide adenine dinucleotide oxidase sequences in all four patients. No other enteric pathogens were found.Conclusions: Although all patients appeared to respond to antibiotic treatment, the clinical significance of B. aalborgi as a human pathogen requires further investigation.",

keywords = "Abdominal pain, Brachyspira, Colon, Diarrhea, Spirochetosis",

author = "HEINE, {RALF G} and WARD, {PETER B} and MIKOSZA, {ANDREW SJ} and VICKI BENNETT-WOOD and ROBINS-BROWNE, {ROY M} and HAMPSON, {DAVID J}",

year = "2001",

month = aug,

doi = "10.1046/j.1440-1746.2001.t01-1-02543.x",

language = "English",

volume = "16",

pages = "872--875",

journal = "Journal of Gastroenterology and Hepatology (Australia)",

issn = "0815-9319",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Brachyspira aalborgi infection in four Australian children

AU - HEINE, RALF G

AU - WARD, PETER B

AU - MIKOSZA, ANDREW SJ

AU - BENNETT-WOOD, VICKI

AU - ROBINS-BROWNE, ROY M

AU - HAMPSON, DAVID J

PY - 2001/8

Y1 - 2001/8

N2 - Aim: The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9–16 years) with colorectal spirochetosis is discussed.Results: Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal spirochetosis was an unanticipated finding on colonic histology, and the presence of spirochetes was confirmed by the use of electron microscopy. Spirochetes were identified as Brachyspira aalborgi by using PCR amplification of the bacterial 16S rRNA and nicotinamide adenine dinucleotide oxidase sequences in all four patients. No other enteric pathogens were found.Conclusions: Although all patients appeared to respond to antibiotic treatment, the clinical significance of B. aalborgi as a human pathogen requires further investigation.

AB - Aim: The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9–16 years) with colorectal spirochetosis is discussed.Results: Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal spirochetosis was an unanticipated finding on colonic histology, and the presence of spirochetes was confirmed by the use of electron microscopy. Spirochetes were identified as Brachyspira aalborgi by using PCR amplification of the bacterial 16S rRNA and nicotinamide adenine dinucleotide oxidase sequences in all four patients. No other enteric pathogens were found.Conclusions: Although all patients appeared to respond to antibiotic treatment, the clinical significance of B. aalborgi as a human pathogen requires further investigation.

KW - Abdominal pain

KW - Brachyspira

KW - Colon

KW - Diarrhea

KW - Spirochetosis

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-0034829646&origin=recordpage

U2 - 10.1046/j.1440-1746.2001.t01-1-02543.x

DO - 10.1046/j.1440-1746.2001.t01-1-02543.x

M3 - RGC 21 - Publication in refereed journal

SN - 0815-9319

VL - 16

SP - 872

EP - 875

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

IS - 8

ER -

Brachyspira aalborgi infection in four Australian children

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