Elucidation and Heterologous Reconstitution of Chrodrimanin B Biosynthesis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

9 Scopus Citations
View graph of relations

Author(s)

  • Tongxuan Bai
  • Zhiyang Quan
  • Rui Zhai
  • Takayoshi Awakawa
  • Ikuro Abe

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)7504−7508
Journal / PublicationOrganic Letters
Volume20
Issue number23
Online published12 Nov 2018
Publication statusPublished - 7 Dec 2018

Abstract

The biosynthetic gene cluster of the fungal meroterpenoid chrodrimanin B (4) was discovered in Penicillium verruculosum TPU1311, and the complete biosynthetic pathway of 4 has been elucidated by heterologous reconstitution of its biosynthesis in Aspergillus oryzae, as well as by in vitro characterizations of selected enzymes. The present study has identified the polyketide synthase that produces 6-hydroxymellein (3) and also provided a biosynthetic platform of chrodrimanins for further bioengineering.

Citation Format(s)

Elucidation and Heterologous Reconstitution of Chrodrimanin B Biosynthesis. / Bai, Tongxuan; Quan, Zhiyang; Zhai, Rui; Awakawa, Takayoshi; Matsuda, Yudai; Abe, Ikuro.

In: Organic Letters, Vol. 20, No. 23, 07.12.2018, p. 7504−7508.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal