Elevated maternal C-reactive protein and autism in a national birth cohort

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

250 Scopus Citations
View graph of relations

Author(s)

  • A. S. Brown
  • A. Sourander
  • S. Hinkka-Yli-Salomäki
  • J. Sundvall
  • H. M. Surcel

Detail(s)

Original languageEnglish
Pages (from-to)259-264
Journal / PublicationMolecular Psychiatry
Volume19
Issue number2
Publication statusPublished - Feb 2014
Externally publishedYes

Abstract

Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP), an established inflammatory biomarker, prospectively assayed in maternal sera, and childhood autism in a large national birth cohort with an extensive serum biobank. Other strengths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million) over the study period and national psychiatric registries consisting of virtually all treated autism cases in the population. Increasing maternal CRP levels, classified as a continuous variable, were significantly associated with autism in offspring. For maternal CRP levels in the highest quintile, compared with the lowest quintile, there was a significant, 43% elevated risk. This finding suggests that maternal inflammation may have a significant role in autism, with possible implications for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopmental disorders. © 2014 Macmillan Publishers Limited All rights reserved.

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Elevated maternal C-reactive protein and autism in a national birth cohort. / Brown, A. S.; Sourander, A.; Hinkka-Yli-Salomäki, S. et al.
In: Molecular Psychiatry, Vol. 19, No. 2, 02.2014, p. 259-264.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review