Element-free multiscale modeling of large deformation behavior of red blood cell membrane with malaria infection

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)Not applicablepeer-review

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Detail(s)

Original languageEnglish
Title of host publicationProceedings of the 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017)
Place of PublicationPittsburgh, USA
Pages316-319
Volume1
ISBN (Electronic)2227-9385
Publication statusPublished - 10 Apr 2017

Publication series

NameCMBE Series
Volume1
ISSN (Print)2227-3085
ISSN (Electronic)2227-9385

Conference

Title5th International Conference on Computational and Mathematical Biomedical Engineering – CMBE2017
Location
PlaceUnited States
City
Period10 - 12 April 2017

Abstract

In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they pass through the microcapillaries and the spleen. In this paper, we examine the effects of Plasmodium falciparum infection and maturation on the large deformation behavior of malaria-infected red blood cells (iRBCs) by means of a three-dimensional (3D) multiscale meshfree method. We numerically simulated the optical tweezers experiment and observed the force-displacement response of the iRBC membrane as malaria infection progresses. Our simulation results agree well with experimental data and confirm that the deformability of malaria-infected cells decreases significantly as malaria infection progresses.

Research Area(s)

  • Red blood cells, Deformability, Multiscale meshfree method, Malaria infection

Citation Format(s)

Element-free multiscale modeling of large deformation behavior of red blood cell membrane with malaria infection. / ADEMILOYE, Adesola Samson; ZHANG, Luwen; LIEW, Kim Meow.

Proceedings of the 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Vol. 1 Pittsburgh, USA, 2017. p. 316-319 (CMBE Series; Vol. 1).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)Not applicablepeer-review