Elemental analysis of the thyroid by laser induced breakdown spectroscopy

IRFAN AHMED; RAFAY AHMED; JINGWEI YANG; ALAN WING LUN LAW; YANPENG ZHANG; CONDON LAU

doi:10.1364/BOE.8.004865

Elemental analysis of the thyroid by laser induced breakdown spectroscopy

IRFAN AHMED, RAFAY AHMED, JINGWEI YANG, ALAN WING LUN LAW, YANPENG ZHANG, CONDON LAU^*

^*Corresponding author for this work

Department of Physics

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

27 Citations (Scopus)

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Abstract

The thyroid is an important hormone regulation organ. Laser induced breakdown spectroscopy (LIBS) is developed to assess iodine and other essential elements in the thyroid (of rats). Subjects are administered 0.05% iodine water for 0, 6, and 12 days before the thyroid is extracted. Pronounced iodine, sodium, calcium, and potassium emissions are observed at approximately 746, 589, 395/422, and 766/770 nm, respectively. Iodine emission is surprisingly highest in 0 day subjects, lowest after 6 days, and recovers by 12 days. This follows the Wolff–Chaikoff effect as ingestion of excess iodine reduces thyroid iodine and iodine is essential for hormone production. LIBS is a promising method for trace elemental analysis of the thyroid.

Original language	English
Article number	#305043
Pages (from-to)	4865-4871
Journal	Biomedical Optics Express
Volume	8
Issue number	11
Online published	6 Oct 2017
DOIs	https://doi.org/10.1364/BOE.8.004865
Publication status	Published - 1 Nov 2017

Research Keywords

Spectroscopy
laser induced breakdown
Tissue characterization

Publisher's Copyright Statement

© 2017 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.

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AU - YANG, JINGWEI

AU - LAW, ALAN WING LUN

AU - ZHANG, YANPENG

AU - LAU, CONDON

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N2 - The thyroid is an important hormone regulation organ. Laser induced breakdown spectroscopy (LIBS) is developed to assess iodine and other essential elements in the thyroid (of rats). Subjects are administered 0.05% iodine water for 0, 6, and 12 days before the thyroid is extracted. Pronounced iodine, sodium, calcium, and potassium emissions are observed at approximately 746, 589, 395/422, and 766/770 nm, respectively. Iodine emission is surprisingly highest in 0 day subjects, lowest after 6 days, and recovers by 12 days. This follows the Wolff–Chaikoff effect as ingestion of excess iodine reduces thyroid iodine and iodine is essential for hormone production. LIBS is a promising method for trace elemental analysis of the thyroid.

AB - The thyroid is an important hormone regulation organ. Laser induced breakdown spectroscopy (LIBS) is developed to assess iodine and other essential elements in the thyroid (of rats). Subjects are administered 0.05% iodine water for 0, 6, and 12 days before the thyroid is extracted. Pronounced iodine, sodium, calcium, and potassium emissions are observed at approximately 746, 589, 395/422, and 766/770 nm, respectively. Iodine emission is surprisingly highest in 0 day subjects, lowest after 6 days, and recovers by 12 days. This follows the Wolff–Chaikoff effect as ingestion of excess iodine reduces thyroid iodine and iodine is essential for hormone production. LIBS is a promising method for trace elemental analysis of the thyroid.

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KW - Tissue characterization

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Elemental analysis of the thyroid by laser induced breakdown spectroscopy

Abstract

Research Keywords

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