Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

Hanbai Wu; Xiong Zhou; Chuanwei Zhi; Cong Wang; Yuhan Chen; Yifan Si; Jieqiong Yang; Qi Zhang; Raymond H. W. Lam; Tingwu Qin; Guibing Fu; Zhu Xiong; Jinlian Hu

doi:10.1002/adhm.202404266

Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

Hanbai Wu, Xiong Zhou, Chuanwei Zhi, Cong Wang, Yuhan Chen, Yifan Si, Jieqiong Yang, Qi Zhang, Raymond H. W. Lam, Tingwu Qin, Guibing Fu, Zhu Xiong, Jinlian Hu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

1 Citation (Scopus)

Abstract

Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing. © 2025 Wiley-VCH GmbH.

Original language	English
Article number	2404266
Journal	Advanced Healthcare Materials
DOIs	https://doi.org/10.1002/adhm.202404266
Publication status	Online published - 10 Jan 2025

Funding

H.W. and X.Z. contributed equally to this work. The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China with the title of “Study of high performance fiber to be achieved by mimicking the hierarchical structure of spider-silk” (Grant No. 52073241), the Contract Research with the title of “Development of breathable fabrics with nano-electrospun membrane” (CityU ref.: 9231419), “Development of Sensational Beauty Mask Materials” (CityU ref.: 9239087), “Development of warmth retention membrane with water vapor permeability” (CityU ref.: 9239088), and “Research and application of antibacterial and healing-promoting smart nanofiber dressing for children's burn wounds” (CityU ref: PJ9240111). The design and studies of animal experiment have followed the animal ethical committee of TOP Biotechnology Co., Ltd. (No. TOP-IACUC-2024-0069). Figure 1 was created with BioRender.com.

Research Keywords

antimicrobial
burn wound healing
electroactive
scarless
self-pumping

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title = "Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management",

abstract = "Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing. {\textcopyright} 2025 Wiley-VCH GmbH.",

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author = "Hanbai Wu and Xiong Zhou and Chuanwei Zhi and Cong Wang and Yuhan Chen and Yifan Si and Jieqiong Yang and Qi Zhang and Lam, {Raymond H. W.} and Tingwu Qin and Guibing Fu and Zhu Xiong and Jinlian Hu",

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doi = "10.1002/adhm.202404266",

language = "English",

journal = "Advanced Healthcare Materials",

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publisher = "John Wiley & Sons",

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TY - JOUR

T1 - Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

AU - Wu, Hanbai

AU - Zhou, Xiong

AU - Zhi, Chuanwei

AU - Wang, Cong

AU - Chen, Yuhan

AU - Si, Yifan

AU - Yang, Jieqiong

AU - Zhang, Qi

AU - Lam, Raymond H. W.

AU - Qin, Tingwu

AU - Fu, Guibing

AU - Xiong, Zhu

AU - Hu, Jinlian

PY - 2025/1/10

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N2 - Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing. © 2025 Wiley-VCH GmbH.

AB - Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing. © 2025 Wiley-VCH GmbH.

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KW - burn wound healing

KW - electroactive

KW - scarless

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ER -

Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

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SZSTIB-C-HK: 兒童燒傷創面抗菌促修復納米纖維智能敷料的研究與應用

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Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

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Funding

Research Keywords

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SZSTIB-C-HK: 兒童燒傷創面抗菌促修復納米纖維智能敷料的研究與應用

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