TY - JOUR
T1 - Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management
AU - Wu, Hanbai
AU - Zhou, Xiong
AU - Zhi, Chuanwei
AU - Wang, Cong
AU - Chen, Yuhan
AU - Si, Yifan
AU - Yang, Jieqiong
AU - Zhang, Qi
AU - Lam, Raymond H. W.
AU - Qin, Tingwu
AU - Fu, Guibing
AU - Xiong, Zhu
AU - Hu, Jinlian
PY - 2025/1/10
Y1 - 2025/1/10
N2 - Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing. © 2025 Wiley-VCH GmbH.
AB - Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing. © 2025 Wiley-VCH GmbH.
KW - antimicrobial
KW - burn wound healing
KW - electroactive
KW - scarless
KW - self-pumping
UR - http://www.scopus.com/inward/record.url?scp=85214801697&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85214801697&origin=recordpage
U2 - 10.1002/adhm.202404266
DO - 10.1002/adhm.202404266
M3 - RGC 21 - Publication in refereed journal
SN - 2192-2640
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
M1 - 2404266
ER -