Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

Hanbai Wu, Xiong Zhou, Chuanwei Zhi, Cong Wang, Yuhan Chen, Yifan Si, Jieqiong Yang, Qi Zhang, Raymond H. W. Lam, Tingwu Qin, Guibing Fu, Zhu Xiong, Jinlian Hu*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

1 Citation (Scopus)

Abstract

Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing. © 2025 Wiley-VCH GmbH.
Original languageEnglish
Article number2404266
JournalAdvanced Healthcare Materials
DOIs
Publication statusOnline published - 10 Jan 2025

Funding

H.W. and X.Z. contributed equally to this work. The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China with the title of “Study of high performance fiber to be achieved by mimicking the hierarchical structure of spider-silk” (Grant No. 52073241), the Contract Research with the title of “Development of breathable fabrics with nano-electrospun membrane” (CityU ref.: 9231419), “Development of Sensational Beauty Mask Materials” (CityU ref.: 9239087), “Development of warmth retention membrane with water vapor permeability” (CityU ref.: 9239088), and “Research and application of antibacterial and healing-promoting smart nanofiber dressing for children's burn wounds” (CityU ref: PJ9240111). The design and studies of animal experiment have followed the animal ethical committee of TOP Biotechnology Co., Ltd. (No. TOP-IACUC-2024-0069). Figure 1 was created with BioRender.com.

Research Keywords

  • antimicrobial
  • burn wound healing
  • electroactive
  • scarless
  • self-pumping

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