Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

21 Scopus Citations
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Author(s)

  • Rong Ma
  • Yiping Wang
  • Li Yan
  • Hoi Ching Chan
  • Sung-Kay Chiu
  • Xianfeng Chen

Detail(s)

Original languageEnglish
Pages (from-to)7859-7862
Journal / PublicationChemical Communications
Volume51
Issue number37
Online published30 Mar 2015
Publication statusPublished - 7 May 2015

Abstract

A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

Citation Format(s)

Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. / Ma, Rong; Wang, Yiping; Yan, Li et al.

In: Chemical Communications, Vol. 51, No. 37, 07.05.2015, p. 7859-7862.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review