Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Rong Ma; Yiping Wang; Li Yan; Lili Ma; Zhigang Wang; Hoi Ching Chan; Sung-Kay Chiu; Xianfeng Chen; Guangyu Zhu

doi:10.1039/c4cc09879j

Author(s)

Rong Ma
Yiping Wang
Li Yan
Hoi Ching Chan
Sung-Kay Chiu
Xianfeng Chen

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	7859-7862
Journal / Publication	Chemical Communications
Volume	51
Issue number	37
Online published	30 Mar 2015
Publication status	Published - 7 May 2015

Link(s)

DOI	DOI https://doi.org/10.1039/c4cc09879j Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84928532227&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(317f9a7f-c90c-4a96-beeb-9e053f3cae1f).html

Abstract

A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

Citation Format(s)

[ RIS ] [ BibTeX ]

Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. / Ma, Rong; Wang, Yiping; Yan, Li et al.

In: Chemical Communications, Vol. 51, No. 37, 07.05.2015, p. 7859-7862.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Ma, R, Wang, Y, Yan, L, Ma, L , Wang, Z, Chan, HC, Chiu, S-K, Chen, X & Zhu, G 2015, 'Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin', Chemical Communications, vol. 51, no. 37, pp. 7859-7862. https://doi.org/10.1039/c4cc09879j

Ma, R., Wang, Y., Yan, L., Ma, L., Wang, Z., Chan, H. C., Chiu, S-K., Chen, X., & Zhu, G. (2015). Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. Chemical Communications, 51(37), 7859-7862. https://doi.org/10.1039/c4cc09879j

Ma R, Wang Y, Yan L, Ma L , Wang Z, Chan HC et al. Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. Chemical Communications. 2015 May 7;51(37):7859-7862. Epub 2015 Mar 30. doi: 10.1039/c4cc09879j

Ma, Rong ; Wang, Yiping ; Yan, Li et al. / Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. In: Chemical Communications. 2015 ; Vol. 51, No. 37. pp. 7859-7862.