Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Rong Ma; Yiping Wang; Li Yan; Lili Ma; Zhigang Wang; Hoi Ching Chan; Sung-Kay Chiu; Xianfeng Chen; Guangyu Zhu

doi:10.1039/c4cc09879j

Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Rong Ma
, Yiping Wang
, Li Yan
, Lili Ma
, Zhigang Wang
, Hoi Ching Chan
, Sung-Kay Chiu
, Xianfeng Chen
, Guangyu Zhu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

33 Citations (Scopus)

Abstract

A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

Original language	English
Pages (from-to)	7859-7862
Journal	Chemical Communications
Volume	51
Issue number	37
Online published	30 Mar 2015
DOIs	https://doi.org/10.1039/c4cc09879j
Publication status	Published - 7 May 2015

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title = "Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin",

abstract = "A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.",

author = "Rong Ma and Yiping Wang and Li Yan and Lili Ma and Zhigang Wang and Chan, \{Hoi Ching\} and Sung-Kay Chiu and Xianfeng Chen and Guangyu Zhu",

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language = "English",

volume = "51",

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journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

AU - Ma, Rong

AU - Wang, Yiping

AU - Yan, Li

AU - Ma, Lili

AU - Wang, Zhigang

AU - Chan, Hoi Ching

AU - Chiu, Sung-Kay

AU - Chen, Xianfeng

AU - Zhu, Guangyu

PY - 2015/5/7

Y1 - 2015/5/7

N2 - A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

AB - A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

UR - https://www.scopus.com/pages/publications/84928532227

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84928532227&origin=recordpage

U2 - 10.1039/c4cc09879j

DO - 10.1039/c4cc09879j

M3 - RGC 21 - Publication in refereed journal

C2 - 25854514

SN - 0009-241X

VL - 51

SP - 7859

EP - 7862

JO - Chemical Communications

JF - Chemical Communications

IS - 37

ER -

Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Abstract

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