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Abstract
Visual prosthesis exhibits the capabilities in restoring partial vision function for patients afflicted with retinal degenerative diseases. Natural stimuli consist of aperiodic events spanning over a short temporal duration. However, periodic stimulation is generally used in most studies. In this study, in vivo experiments on both retinal degenerated S334ter-line-3 (F1) rats and Sprague Dawley (SD) rats were performed to explore the impact of aperiodic retinal stimulation on the electrically evoked response in the primary visual cortex (V1) in comparison to periodic stimulation. It was noticed that the periodic retinal stimulation elicited a pronouncedly lower spike rate compared with the aperiodic pattern at frequencies of 10 and 20 Hz in SD rats. F1 rats showed similar but weaker trend. The time precision of responses was also explored. The aperiodic stimulation with 50% noise increased the temporal precision of the cortical response in comparison to periodic stimulation at 20 Hz in both SD and F1 rats. These findings implied a prospective way to improve the performance of the retinal implants from the aspect of temporal precision by using aperiodic stimulation. © 2024 IEEE.
Original language | English |
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Title of host publication | 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
Publisher | IEEE |
ISBN (Electronic) | 979-8-3503-7149-9 |
ISBN (Print) | 979-8-3503-7150-5 |
DOIs | |
Publication status | Published - 2024 |
Event | 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2024): Technology and its promise for equity and access for well-health - Orlando, United States Duration: 15 Jul 2024 → 19 Jul 2024 https://embc.embs.org/2024/ |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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ISSN (Print) | 2375-7477 |
ISSN (Electronic) | 2694-0604 |
Conference
Conference | 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2024) |
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Abbreviated title | IEEE EMBC 2024 |
Country/Territory | United States |
City | Orlando |
Period | 15/07/24 → 19/07/24 |
Internet address |
Funding
The work described in this paper was partially supported by the Research Grant Council of the Hong Kong Special Administrative Region (Grant No. CityU 11207419) and was partially supported by Sichuan Science and Technology Program, Project 2022-YF05-01360-SN, Chengdu Research Institute, City University of Hong Kong.
Research Keywords
- aperiodic stimulation
- cortical response
- electrical stimulation
- periodic stimulation
- rat
- retinal degeneration
Fingerprint
Dive into the research topics of 'Efficacy of Aperiodic Electrical Stimulation in Retina to Enhance Visual Cortical Responses'. Together they form a unique fingerprint.Projects
- 1 Finished
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GRF: Aperiodic Stimulation Patterns for Visual Implants
CHAN, L. H. L. (Principal Investigator / Project Coordinator) & CHEN, K. (Co-Investigator)
1/09/19 → 27/02/24
Project: Research