Effects of water extract of Cajanus cajan leaves on differentiation and function of primary osteoblasts and osteoclasts in vitro

Zhang Jinchao; Ba Cuilan; Ji Xiaoyu; Shen Shigang; Yang Mengsu; Wang Shuxiang

doi:10.1080/13880200902942402

Effects of water extract of Cajanus cajan leaves on differentiation and function of primary osteoblasts and osteoclasts in vitro

Zhang Jinchao
, Ba Cuilan
, Ji Xiaoyu
, Shen Shigang
, Yang Mengsu
, Wang Shuxiang

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

Abstract

The effects of water extract of Cajanus cajan (L.) Millsp. leaves (WECML) on differentiation and function of primary osteoblasts and osteoclasts were studied. The results indicated that WECML inhibited the proliferation of osteoblasts at higher concentration of 100μg/mL and the inhibition rate was 12.12%. When its concentration descended to 0.01∼10μg/mL, it turned to stimulate the proliferation of the osteoblasts. The effects of WECML on differentiation of osteoblasts depended on concentrations and time. It promoted the mineralization function of osteoblasts at concentrations of 0.01, 0.1, and 1μg/mL, but inhibited the mineralization function at concentrations of 10 and 100μg/mL. It inhibited bone resorption activity as indicated by the dose-dependent reduction in the pit numbers and areas (P

Original language	English
Pages (from-to)	841-846
Journal	Pharmaceutical Biology
Volume	47
Issue number	9
DOIs	https://doi.org/10.1080/13880200902942402
Publication status	Published - Sept 2009

Research Keywords

Cajanus cajan (L.) Millsp.
Differentiation
Function
Osteoblasts
Osteoclasts

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10.1080/13880200902942402

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title = "Effects of water extract of Cajanus cajan leaves on differentiation and function of primary osteoblasts and osteoclasts in vitro",

abstract = "The effects of water extract of Cajanus cajan (L.) Millsp. leaves (WECML) on differentiation and function of primary osteoblasts and osteoclasts were studied. The results indicated that WECML inhibited the proliferation of osteoblasts at higher concentration of 100μg/mL and the inhibition rate was 12.12\%. When its concentration descended to 0.01∼10μg/mL, it turned to stimulate the proliferation of the osteoblasts. The effects of WECML on differentiation of osteoblasts depended on concentrations and time. It promoted the mineralization function of osteoblasts at concentrations of 0.01, 0.1, and 1μg/mL, but inhibited the mineralization function at concentrations of 10 and 100μg/mL. It inhibited bone resorption activity as indicated by the dose-dependent reduction in the pit numbers and areas (P",

keywords = "Cajanus cajan (L.) Millsp., Differentiation, Function, Osteoblasts, Osteoclasts",

author = "Zhang Jinchao and Ba Cuilan and Ji Xiaoyu and Shen Shigang and Yang Mengsu and Wang Shuxiang",

year = "2009",

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doi = "10.1080/13880200902942402",

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journal = "Pharmaceutical Biology",

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TY - JOUR

T1 - Effects of water extract of Cajanus cajan leaves on differentiation and function of primary osteoblasts and osteoclasts in vitro

AU - Jinchao, Zhang

AU - Cuilan, Ba

AU - Xiaoyu, Ji

AU - Shigang, Shen

AU - Mengsu, Yang

AU - Shuxiang, Wang

PY - 2009/9

Y1 - 2009/9

N2 - The effects of water extract of Cajanus cajan (L.) Millsp. leaves (WECML) on differentiation and function of primary osteoblasts and osteoclasts were studied. The results indicated that WECML inhibited the proliferation of osteoblasts at higher concentration of 100μg/mL and the inhibition rate was 12.12%. When its concentration descended to 0.01∼10μg/mL, it turned to stimulate the proliferation of the osteoblasts. The effects of WECML on differentiation of osteoblasts depended on concentrations and time. It promoted the mineralization function of osteoblasts at concentrations of 0.01, 0.1, and 1μg/mL, but inhibited the mineralization function at concentrations of 10 and 100μg/mL. It inhibited bone resorption activity as indicated by the dose-dependent reduction in the pit numbers and areas (P

AB - The effects of water extract of Cajanus cajan (L.) Millsp. leaves (WECML) on differentiation and function of primary osteoblasts and osteoclasts were studied. The results indicated that WECML inhibited the proliferation of osteoblasts at higher concentration of 100μg/mL and the inhibition rate was 12.12%. When its concentration descended to 0.01∼10μg/mL, it turned to stimulate the proliferation of the osteoblasts. The effects of WECML on differentiation of osteoblasts depended on concentrations and time. It promoted the mineralization function of osteoblasts at concentrations of 0.01, 0.1, and 1μg/mL, but inhibited the mineralization function at concentrations of 10 and 100μg/mL. It inhibited bone resorption activity as indicated by the dose-dependent reduction in the pit numbers and areas (P

KW - Cajanus cajan (L.) Millsp.

KW - Differentiation

KW - Function

KW - Osteoblasts

KW - Osteoclasts

UR - https://www.scopus.com/pages/publications/77149129043

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-77149129043&origin=recordpage

U2 - 10.1080/13880200902942402

DO - 10.1080/13880200902942402

M3 - RGC 21 - Publication in refereed journal

SN - 1388-0209

VL - 47

SP - 841

EP - 846

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

IS - 9

ER -

Effects of water extract of Cajanus cajan leaves on differentiation and function of primary osteoblasts and osteoclasts in vitro

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Research Keywords

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