TY - JOUR
T1 - Effects of water extract of Cajanus cajan leaves on differentiation and function of primary osteoblasts and osteoclasts in vitro
AU - Jinchao, Zhang
AU - Cuilan, Ba
AU - Xiaoyu, Ji
AU - Shigang, Shen
AU - Mengsu, Yang
AU - Shuxiang, Wang
PY - 2009/9
Y1 - 2009/9
N2 - The effects of water extract of Cajanus cajan (L.) Millsp. leaves (WECML) on differentiation and function of primary osteoblasts and osteoclasts were studied. The results indicated that WECML inhibited the proliferation of osteoblasts at higher concentration of 100μg/mL and the inhibition rate was 12.12%. When its concentration descended to 0.01∼10μg/mL, it turned to stimulate the proliferation of the osteoblasts. The effects of WECML on differentiation of osteoblasts depended on concentrations and time. It promoted the mineralization function of osteoblasts at concentrations of 0.01, 0.1, and 1μg/mL, but inhibited the mineralization function at concentrations of 10 and 100μg/mL. It inhibited bone resorption activity as indicated by the dose-dependent reduction in the pit numbers and areas (P
AB - The effects of water extract of Cajanus cajan (L.) Millsp. leaves (WECML) on differentiation and function of primary osteoblasts and osteoclasts were studied. The results indicated that WECML inhibited the proliferation of osteoblasts at higher concentration of 100μg/mL and the inhibition rate was 12.12%. When its concentration descended to 0.01∼10μg/mL, it turned to stimulate the proliferation of the osteoblasts. The effects of WECML on differentiation of osteoblasts depended on concentrations and time. It promoted the mineralization function of osteoblasts at concentrations of 0.01, 0.1, and 1μg/mL, but inhibited the mineralization function at concentrations of 10 and 100μg/mL. It inhibited bone resorption activity as indicated by the dose-dependent reduction in the pit numbers and areas (P
KW - Cajanus cajan (L.) Millsp.
KW - Differentiation
KW - Function
KW - Osteoblasts
KW - Osteoclasts
UR - http://www.scopus.com/inward/record.url?scp=77149129043&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-77149129043&origin=recordpage
U2 - 10.1080/13880200902942402
DO - 10.1080/13880200902942402
M3 - RGC 21 - Publication in refereed journal
SN - 1388-0209
VL - 47
SP - 841
EP - 846
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 9
ER -