Effects of posterior-anterior shift in the aging brain on creativity : A combined ICA and resting-state fMRI study

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)

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Author(s)

Detail(s)

Original languageEnglish
Title of host publicationA Supplement of the Journal of Cognitive Neuroscience
PublisherMIT Press Journals
Pages124
ISBN (Print)1096-8857
Publication statusPublished - Mar 2020

Conference

Title27th Annual Meeting of Cognitive Neuroscience Society (CNS 2020)
LocationSheraton Hotel
PlaceUnited States
CityBoston
Period14 - 17 March 2020

Abstract

There is converging evidence that cognitive aging is associated with significant changes in functional connectivity between various regions of the aging brain. In the present study, we employed the resting-state functional magnetic resonance imaging (rs-fMRI) technique and independent component analysis (ICA) approach to examine whether and how posterior-anterior shift in aging (i.e., PASA) in functional connectivity of various resting-state networks (RSNs) relates to individual differences in creative ability in the elderly. Group-ICA of RSNs from 34 healthy old adults and 21 young adults were performed to identify default mode network (DMN), executive-control network (ECN), temporal-occipital network, and cerebellar network. Each participant’s creative assessment questionnaire (CAQ) score was used as a covariate to examine the association between mental ability of creativity and functional connectivity of RSNs. The rs-fMRI results demonstrated the stronger connectivity of prefrontal gyri whereas reduced connectivity of temporal-occipital regions for the older adults, consistent with the notion of PASA. Moreover, individual variations in CAQ scores were related to the patterns of PASA in older but not in young adults. Our findings provide the neuroimaging evidence that age-related changes in creative ability may be associated with a posterior-to-anterior gradient of declines in functional connectivity of the aging brain.

Citation Format(s)

Effects of posterior-anterior shift in the aging brain on creativity : A combined ICA and resting-state fMRI study. / Patil, Abhishek Uday; Madathil, Deepa ; Tzeng, Ovid J L; Huang, Hsu-Wen; Huang, Chih-Mao.

A Supplement of the Journal of Cognitive Neuroscience. MIT Press Journals, 2020. p. 124 D126.

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)