Effects of polycyclic aromatic compounds in fine particulate matter generated from household coal combustion on response to EGFR mutations in vitro

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Kin-Fai Ho
  • Chih-Cheng Chang
  • Linwei Tian
  • Chi-Sing Chan
  • Benjamin A. Musa Bandowe
  • Ka-Hei Lui
  • Kang-Yun Lee
  • Kai-Jen Chuang
  • Chien-Ying Liu
  • Hsiao-Chi Chuang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)1262-1269
Journal / PublicationEnvironmental Pollution
Volume218
Publication statusPublished - 1 Nov 2016

Abstract

Induction of PM2.5-associated lung cancer in response to EGFR-tyrosine kinase inhibitors (EGFR-TKI) remains unclear. Polycyclic aromatic hydrocarbons (PAHs) and their polar derivatives (oxygenated PAHs: OPAHs and azaarenes: AZAs) were characterized in fine particulates (PM2.5) emitted from indoor coal combustion. Samples were collected in Xuanwei (Yunnan Province), a region in China with a high rate of lung cancer. Human lung adenocarcinoma cells A549 (with wild-type EGFR) and HCC827 (with EGFR mutation) were exposed to the PM2.5, followed by treatment with EGFR-TKI. Two samples showed significant and dose-dependent reduction in the cell viability in A549. EGFR-TKI further demonstrated significantly decreased in cell viability in A549 after exposure to the coal emissions. Chrysene and triphenylene, dibenzo[a,h]anthracene, benzo[ghi]perylene, azaarenes and oxygenated polycyclic aromatic hydrocarbons (carbonyl-OPAHs) were all associated with EGFR-TKI–dependent reduced cell viability after 72-h exposure to the PM2.5. The findings suggest the coal emissions could influence the response of EGFR-TKI in lung cancer cells in Xuanwei.

Research Area(s)

  • Coal combustion, Lung cancer, Polycyclic aromatic compounds, Xuanwei

Citation Format(s)

Effects of polycyclic aromatic compounds in fine particulate matter generated from household coal combustion on response to EGFR mutations in vitro. / Ho, Kin-Fai; Chang, Chih-Cheng; Tian, Linwei et al.
In: Environmental Pollution, Vol. 218, 01.11.2016, p. 1262-1269.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review