Effects of lanthanum on formation and bone-resorbing activity of osteoclast-like cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jinchao Zhang
  • Tianlan Zhang
  • Shanjin Xu
  • Kui Wang
  • Shifeng Yu

Detail(s)

Original languageEnglish
Pages (from-to)891-895
Journal / PublicationJournal of Rare Earths
Volume22
Issue number6
Publication statusPublished - Dec 2004

Abstract

The effect of La3+ on formation of osteoclast-like cells in rabbit bone marrow cells induced by 1,25-di-hydroxyvitamin D3 and their bone-resorbing activity was evaluated by counting the number of tartrate resistant-acid phosphatase-positive [TRAP(+)] multi-nucleated cells and measuring the number and surface area of bone re-sorption pits with photomicrography and image analysis. The formation and morphological characteristics of osteoclast-like cells and bone resorption pits were observed under a phase contrast inverted microscope. La3+ promotes the formation of osteoclast-like cells at the concentration of 1.00 × 10 mol·L compared with the control group (P <0.01), whereas no significant change in cell number is observed at higher concentrations (1.00 × 10-5, 1.00 × 10-6 and 1.00 × 10-7 mol·L-1) (P > 0.05). La3+ at the concentration of 1.00 × 10-8 mol·L-1 also increases the number and surface area of the resorption pits (P <0.01), but inhibits the bone-resorbing activity dose-dependently (P <0.01) at higher concentrations (1.00 × 10-5, 1.00 × 10-6 and 1.00 × 10-7 mol·L-1). These findings suggest that La3+ may promote or inhibit the formation and bone-resorbing activity of osteoclast-like cells depending on its concentration.

Research Area(s)

  • 1, 25-dihydroxy vitamin D3, Bone marrow cells, Bone resorption, Lanthanum, Osteoclast-like cells, Rare earths

Citation Format(s)

Effects of lanthanum on formation and bone-resorbing activity of osteoclast-like cells. / Zhang, Jinchao; Zhang, Tianlan; Xu, Shanjin; Wang, Kui; Yu, Shifeng; Yang, Mengsu.

In: Journal of Rare Earths, Vol. 22, No. 6, 12.2004, p. 891-895.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review