Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Pages (from-to) | 618-623 |
Journal / Publication | Progress in Natural Science |
Volume | 17 |
Issue number | 5 |
Publication status | Published - May 2007 |
Link(s)
Abstract
The effects of La3+ and Gd3+ on the proliferation, differentiation and adipogenic transdifferentiation of rat calvarial osteoblast-like cells (ROB cells) were evaluated by MTT method, measuring the activity of alkaline phosphatase (ALP) and Oil red O measurement. Both of La3+ and Gd3+ inhibited the proliferation of ROB cells at all concentrations (1 × 10-5, 1 × 10-6, 1 × 10-7, 1 × 10-8, 1 × 10-9 mol · L-1). La3+ at concentration of 1 × 10-5 mol · L-1 significantly increased the alkaline phosphatase activity of ROB cells up to 3 folds (P3+ inhibited the adipogenic transdifferentiation of ROB cells at all concentrations in a dose-dependent way. However, Gd3+ promoted the adipogenic transdifferentiation of ROB cells at 1 × 10-8 and 1 × 10-9 mol · L-1. These findings suggested that the effects of rare earth elements on the proliferation, differentiation and adipogenic transdifferentiation of ROB cells were dependent on their concentrations and species.
Research Area(s)
- Differentiation, Gadolinium, Lanthanum, Osteoblast-like cells, Proliferation, Transdifferentiation
Citation Format(s)
Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts. / Zhang, Dawei; Zhang, Jinchao; Chen, Yao et al.
In: Progress in Natural Science, Vol. 17, No. 5, 05.2007, p. 618-623.
In: Progress in Natural Science, Vol. 17, No. 5, 05.2007, p. 618-623.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review