Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts

Dawei Zhang; Jinchao Zhang; Yao Chen; Mengsu Yang; Xinsheng Yao

doi:10.1080/10020070708541044

Author(s)

Dawei Zhang
Jinchao Zhang
Yao Chen
Mengsu Yang
Xinsheng Yao

Related Research Unit(s)

Shenzhen Research Institute

Detail(s)

Original language	English
Pages (from-to)	618-623
Journal / Publication	Progress in Natural Science
Volume	17
Issue number	5
Publication status	Published - May 2007

Link(s)

DOI	DOI https://doi.org/10.1080/10020070708541044 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-34249990030&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(78138d18-9fb2-4c00-a080-95841b7e3b30).html

Abstract

The effects of La³⁺ and Gd³⁺ on the proliferation, differentiation and adipogenic transdifferentiation of rat calvarial osteoblast-like cells (ROB cells) were evaluated by MTT method, measuring the activity of alkaline phosphatase (ALP) and Oil red O measurement. Both of La³⁺ and Gd³⁺ inhibited the proliferation of ROB cells at all concentrations (1 × 10^-5, 1 × 10^-6, 1 × 10^-7, 1 × 10^-8, 1 × 10^-9 mol · L^-1). La³⁺ at concentration of 1 × 10^-5 mol · L^-1 significantly increased the alkaline phosphatase activity of ROB cells up to 3 folds (P3+ inhibited the adipogenic transdifferentiation of ROB cells at all concentrations in a dose-dependent way. However, Gd³⁺ promoted the adipogenic transdifferentiation of ROB cells at 1 × 10^-8 and 1 × 10^-9 mol · L^-1. These findings suggested that the effects of rare earth elements on the proliferation, differentiation and adipogenic transdifferentiation of ROB cells were dependent on their concentrations and species.

Research Area(s)

Differentiation, Gadolinium, Lanthanum, Osteoblast-like cells, Proliferation, Transdifferentiation

Citation Format(s)

[ RIS ] [ BibTeX ]

Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts. / Zhang, Dawei; Zhang, Jinchao; Chen, Yao et al.
In: Progress in Natural Science, Vol. 17, No. 5, 05.2007, p. 618-623.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Zhang, D, Zhang, J, Chen, Y, Yang, M & Yao, X 2007, 'Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts', Progress in Natural Science, vol. 17, no. 5, pp. 618-623. https://doi.org/10.1080/10020070708541044

Zhang, D., Zhang, J., Chen, Y., Yang, M., & Yao, X. (2007). Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts. Progress in Natural Science, 17(5), 618-623. https://doi.org/10.1080/10020070708541044

Zhang D, Zhang J, Chen Y, Yang M, Yao X. Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts. Progress in Natural Science. 2007 May;17(5):618-623. doi: 10.1080/10020070708541044

Zhang, Dawei ; Zhang, Jinchao ; Chen, Yao et al. / Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts. In: Progress in Natural Science. 2007 ; Vol. 17, No. 5. pp. 618-623.