Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in pigletse

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jie Yin
  • Mingfeng Liu
  • Wenkai Ren
  • Jielin Duan
  • Yurong Zhao
  • Rejun Fang
  • Lixiang Chen
  • Tiejun Li
  • Yulong Yin

Detail(s)

Original languageEnglish
Article number0122893
Journal / PublicationPLOS ONE
Volume10
Issue number4
Publication statusPublished - 15 Apr 2015
Externally publishedYes

Link(s)

Abstract

This study aimed to investigate the protective effects of dietary glutamate and aspartate supplementations on diquat-induced oxidative stress in piglets. Diquat injection significantly reduced growth performance, including body weight, average daily weight gain, and feed intake (P<0.05). Meanwhile, diquat administration induced oxidative stress evidenced by the decreased serum nitric oxide (NO) and elevated malondialdeyhde (MDA) concentration (P<0.05). Furthermore, diquat-induced oxidative stress disrupted intestinal absorption system and decreased serum threonine, serine, and glycine levels. Dietary supplementation with glutamate improved final body weight, antioxidant system, and expressions of amino acids transporters and enhanced serum glutamate concentration compared with diquat group (P<0.05). While aspartate failed to alleviate diquat-induced oxidative stress, growth depression, and dysfunction of nutrients absorption except for liver relative weight. In conclusion, dietary supplementation with glutamate confers beneficial effects on diquat-induced oxidative stress in piglets, while aspartate exhibits little effects.

Research Area(s)

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in pigletse. / Yin, Jie; Liu, Mingfeng; Ren, Wenkai et al.
In: PLOS ONE, Vol. 10, No. 4, 0122893, 15.04.2015.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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