Effects of dietary exposure to ciguatoxin P-CTX-1 on the reproductive performance in marine medaka (Oryzias melastigma)

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

18 Scopus Citations
View graph of relations


  • Maggie Y.L. Mak
  • Jinping Cheng
  • Priscilla T.Y. Leung
  • Paul K.S. Lam


Original languageEnglish
Article number110837
Journal / PublicationMarine Pollution Bulletin
Online published25 Jan 2020
Publication statusPublished - Mar 2020


Ciguatoxins are natural compounds produced by benthic dinoflagellates Gambierdiscus and Fukuyoa spp., which cause fish intoxication by ciguatera fish poisoning. This study aimed to assess the dietary exposure effects of ciguatoxin P-CTX-1 on the reproductive performance in marine medaka (Oryzias melastigma). Fish which ingested >1.16 pg·day−1 for 21 days exhibited abnormal behaviors including diarrhea, abnormal swimming, loss of appetite and decreased egg production. After 7-day exposure to P-CTX-1 at a dose of 1.93 pg·day−1, significant gender-specific differences in reproductive performance and decreased hatching rate of the offspring were observed. Chemical analysis of P-CTX-1 showed that the P-CTX-1 accumulation rates were 24.1 ± 1.4% in female fish and 9.9 ± 0.4% in male fish, and 0.05 pg·egg−1 was detected. The results illustrate that dietary exposure to P-CTX-1 affected the reproductive performance and survival of offspring, and caused bioaccumulation and maternal transfer of P-CTX-1 in marine medaka.

Research Area(s)

  • Bio-encapsulation, Ciguatoxin, Gambierdiscus, Maternal transfer, Oryzias melastigma, Reproduction

Citation Format(s)