Effects of Bis(imino)acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA Interactions, and Redox Activity of Palladium(II) Bipyridine Complexes

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Veronika I. Komlyagina
  • Nikolai F. Romashev
  • Victoria K. Besprozvannykh
  • Alexey S. Chubarov
  • Ivan V. Bakaev
  • Yee Kiat Soh
  • Pavel A. Abramov
  • Kin Leung Cheung
  • Nikolai B. Kompan'kov
  • Aleksey A. Ryadun
  • Artem L. Gushchin

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)11541-11553
Journal / PublicationInorganic Chemistry
Volume62
Issue number29
Online published7 Jul 2023
Publication statusPublished - 24 Jul 2023

Abstract

A series of heteroleptic bipyridine Pd(II) complexes based on 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (dpp-Bian) or 1,2-bis[(2,4,6-trimethylphenyl)imino]acenaphthene (tmp-Bian) were prepared. All complexes were fully characterized by spectrochemical methods, and their crystal structures were confirmed by X-ray diffraction analysis. The 72 h stability of heteroleptic bipyridine Pd(II) complexes with Bian ligands under physiological conditions was investigated using 1H NMR spectroscopy. The anticancer activity of all complexes was assessed in a panel of cancer cell lines in comparison with uncoordinated ligands and clinically used drugs cisplatin and doxorubicin. The ability of the complexes to bind DNA was investigated using several methods, including EtBr replacement assay, density functional theory calculations, circular dichroism spectroscopy, DNA gel electrophoresis, and TUNEL assay. The electrochemical activity of all complexes and the uncoordinated ligands was studied using cyclic voltammetry, and reactive oxygen species production in cancer cells was investigated using confocal microscopy. Heteroleptic bipyridine PdII-Bian complexes were cytotoxic in a low micromolar concentration range and showed some selectivity toward cancer cells in comparison with noncancerous MRC-5 lung fibroblasts. © 2023 American Chemical Society.

Research Area(s)

  • HETEROCYCLIC CARBENE COMPLEXES, COPPER(II) COMPLEXES, ACENAPHTHENE-1,2-DIIMINE LIGAND, INSERTION POLYMERIZATION, BULKY, SUBSTITUENTS, SPECTROSCOPY, REDUCTION, CISPLATIN, APOPTOSIS

Citation Format(s)

Effects of Bis(imino)acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA Interactions, and Redox Activity of Palladium(II) Bipyridine Complexes. / Komlyagina, Veronika I.; Romashev, Nikolai F.; Besprozvannykh, Victoria K. et al.
In: Inorganic Chemistry, Vol. 62, No. 29, 24.07.2023, p. 11541-11553.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review