Effects of alendronate sodium on osteogenic and adipogenic differentiation of bone marrow stromal cells

Research output: Journal Publications and Reviews › RGC 22 - Publication in policy or professional journal

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Author(s)

  • Xiang-Hui Li
  • Zhi-Jian Lu
  • Jin-Chao Zhang
  • Yao Chen
  • Sen-Fang Sui

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)671-674
Journal / PublicationChinese Pharmacological Bulletin
Volume22
Issue number6
Publication statusPublished - Jun 2006

Link(s)

Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-33747191788&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(72a60f35-6da8-467b-a1c4-696ed80b897d).html

Abstract

Aim: To study the effects of alendronate sodium on osteogenic and adipogenic differentiation of primary mouse bone marrow stromal cells (MSCs). Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), alkaline phosphatase (ALP) activity assay and Oil Red assay were used to investigate the effects of alendronate sodium on the growth, ostogenesis and adipogenesis of MSCs, respectively. Results: Alendronate sodium promoted the proliferation of primary mouse bone marrow stromal cells, inhibited osteogenic differentiation and adipogenic differentiation of MSCs at concentrations of 1 × 10-10, 1 × 10-9, 1 × 10-8, 1 × 10-7, 1 × 10-6 and 1 × 10 -5 mol. L-1, respectively (P <0.05). Conclusion: Alendronate sodium may have preventive and therapectic effects on osteoporosis by inhibiting adipogenesis of MSCs, thorough reducing cytokines secretion by adipocytes to inhibit formation, activation and bone resorption of osteoclasts.

Research Area(s)

  • Adipogenic differentiation, Alendronate sodium, Bone marrow stromal cells, Osteogenic differentiation

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Stromal Cell Biochemistry, Genetics an...
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Adipogenesis Biochemistry, Genetics an...
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Osteogenic Differen... Keyphrases
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Adipogenic Differen... Keyphrases
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Human Mesenchymal S... Keyphrases
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Alendronate Sodium Keyphrases
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Alendronic Acid Pharmacology, Toxicology ...
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sodium INIS
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bone marrow INIS
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Marrow Stromal Cell... Keyphrases
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Citation Format(s)

[ RIS ] [ BibTeX ]
Effects of alendronate sodium on osteogenic and adipogenic differentiation of bone marrow stromal cells. / Li, Xiang-Hui; Lu, Zhi-Jian; Zhang, Jin-Chao et al.
In: Chinese Pharmacological Bulletin, Vol. 22, No. 6, 06.2006, p. 671-674.

Research output: Journal Publications and Reviews › RGC 22 - Publication in policy or professional journal