Effectiveness of mesenchymal stem cell therapy in cats with chronic gingivostomatitis

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • San Tung Wong
  • Tiffany Ka Yi Leung
  • Qi An Ngai
  • Wing Sum Wong

Detail(s)

Original languageEnglish
Journal / PublicationVeterinary Evidence
Volume9
Issue number1
Online published7 Feb 2024
Publication statusPublished - 2024

Link(s)

Abstract

PICO question
In cats with chronic gingivostomatitis, does using intravenous mesenchymal stem cell therapy, compared to not using it, lead to the improvement of clinical signs?

Clinical bottom line

Category of research     Treatment.

Number and type of study designs reviewed     Five interventional studies (clinical trials).

Strength of evidence     Moderate.

Outcomes reported     The reviewed studies indicate intravenous mesenchymal stem cell (MSC) therapy is safe to administer and can be effective in remission or alleviating the clinical signs of refractory, chronic gingivostomatitis in cats that have undergone full-mouth tooth extraction.

Conclusion     The collective evidence supports the intravenous administration of mesenchymal stem cell (MSC) therapy in cats with chronic gingivostomatitis following dental extraction. However, conducted clinical trials are prone to different degrees of bias due to the lack of independent control groups, the small number of subjects, and enrolling subjects with various severity of the disease. Therefore, more robust evidence can be obtained through well-designed randomised controlled trials to confirm the observed positive effects of the treatment in cats with a broader range of characteristics.

© 2024 Omid Nekouei, San Tung Wong, Tiffany Ka Yi Leung, Qi An Ngai, Wing Sum Wong & Angel Almendros.

Research Area(s)

  • CATS, FELINE, FELINE CHRONICGINGIVOSTOMATITIS, REFRACTORY, STEM CELL, TREATMENT

Citation Format(s)

Effectiveness of mesenchymal stem cell therapy in cats with chronic gingivostomatitis. / Nekouei, Omid; Wong, San Tung; Leung, Tiffany Ka Yi et al.
In: Veterinary Evidence, Vol. 9, No. 1, 2024.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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