Effective Phototheranostics of Brain Tumor Assisted by Near-Infrared-II Light-Responsive Semiconducting Polymer Nanoparticles

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)33492-33499
Journal / PublicationACS applied materials & interfaces
Volume12
Issue number30
Online published6 Jul 2020
Publication statusPublished - 29 Jul 2020

Abstract

Precise diagnosis and effective treatment of gliomas still remain a huge challenge. Photoacoustic-guided photothermal therapy (PTT) has unique advantages over conventional techniques for brain tumor theranostics, but existing nanoagents for photoacoustic imaging (PAI)-guided PTT are mainly organic small molecules or inorganic nanoparticles, which have the limitations of poor photostability and biocompatibility. Besides, the restricted absorption in the first near-infrared window (NIR-I) of the most existing nanoagents compromises their effectiveness for deep tissue PAI and PTT. We herein develop novel semiconducting polymer nanoparticles (SPNs) that are strongly absorptive in the second NIR window (NIR-II) to alleviate these problems. With the merits of excellent photoacoustic and photothermal performance, high photostability, proper size, and low toxicity, SPNs not only show efficient cellular uptake for PAI and PTT toward U87 glioma cells but also demonstrate effective accumulation in both subcutaneous tumors and brain tumors upon intravenous injection, thereby realizing efficient PAI-guided PTT toward gliomas under NIR-II light irradiation.

Research Area(s)

  • brain tumor, near-infrared-II light, photoacoustic imaging, photothermal therapy, semiconducting polymer nanoparticle

Citation Format(s)

Effective Phototheranostics of Brain Tumor Assisted by Near-Infrared-II Light-Responsive Semiconducting Polymer Nanoparticles. / Wen, Guohua; Li, Xiaozhen; Zhang, Yachao; Han, Xiongqi; Xu, Xiayi; Liu, Chao; Chan, Kannie W. Y.; Lee, Chun-Sing; Yin, Chao; Bian, Liming; Wang, Lidai.

In: ACS applied materials & interfaces, Vol. 12, No. 30, 29.07.2020, p. 33492-33499.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review