Effective Light Directed Assembly of Building Blocks with Microscale Control

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

10 Scopus Citations
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Author(s)

  • Ngoc-Duy Dinh
  • Rongcong Luo
  • Maria Tankeh Asuncion Christine
  • Weikang Nicholas Lin
  • Wei-Chuan Shih
  • James Cho-Hong Goh

Detail(s)

Original languageEnglish
Article number1700684
Journal / PublicationSmall
Volume13
Issue number24
Online published8 May 2017
Publication statusPublished - 27 Jun 2017
Externally publishedYes

Abstract

Light-directed forces have been widely used to pattern micro/nanoscale objects with precise control, forming functional assemblies. However, a substantial laser intensity is required to generate sufficient optical gradient forces to move a small object in a certain direction, causing limited throughput for applications. A high-throughput light-directed assembly is demonstrated as a printing technology by introducing gold nanorods to induce thermal convection flows that move microparticles (diameter = 40 µm to several hundreds of micrometers) to specific light-guided locations, forming desired patterns. With the advantage of effective light-directed assembly, the microfluidic-fabricated monodispersed biocompatible microparticles are used as building blocks to construct a structured assembly (≈10 cm scale) in ≈2 min. The control with microscale precision is approached by changing the size of the laser light spot. After crosslinking assembly of building blocks, a novel soft material with wanted pattern is approached. To demonstrate its application, the mesenchymal stem-cell-seeded hydrogel microparticles are prepared as functional building blocks to construct scaffold-free tissues with desired structures. This light-directed fabrication method can be applied to integrate different building units, enabling the bottom-up formation of materials with precise control over their internal structure for bioprinting, tissue engineering, and advanced manufacturing.

Research Area(s)

  • bottom-up tissue engineering, effective light directed-assembly, hydrogel building blocks, microscale manipulation

Citation Format(s)

Effective Light Directed Assembly of Building Blocks with Microscale Control. / Dinh, Ngoc-Duy; Luo, Rongcong; Christine, Maria Tankeh Asuncion; Lin, Weikang Nicholas; Shih, Wei-Chuan; Goh, James Cho-Hong; Chen, Chia-Hung.

In: Small, Vol. 13, No. 24, 1700684, 27.06.2017.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal