EFFECT OF XENOGENEIC MESENCHYMAL STEM CELL SECRETOME ON REFRACTORY FELINE CHRONIC GINGIVOSTOMATITIS

Research output: Conference PapersRGC 33 - Other conference paperpeer-review

View graph of relations

Detail(s)

Original languageEnglish
Publication statusPresented - 27 Sept 2023

Conference

Title48th World Small Animal Veterinary Association Congress (WSAVA 2023) and 28th Federation of European Companion Animal Veterinary Associations (FECAVA) Eurocongress
PlacePortugal
CityLisbon
Period27 - 29 September 2023

Abstract

Introduction:

Consistent successful treatment of feline chronic gingivostomatitis (FCGST) remains elusive. Even after surgery, 30% of cats require long term treatment with corticosteroids or cyclosporin. Autologous and allogeneic mesenchymal stem cells (MSCs) improved or cured FCGST in 70% of cats in previous studies. Secretome from MSCs appear to potentially exhibit functions including inflammatory control, regeneration, and healing of injured tissue.

Objectives:

To investigate the effect of xenogeneic adipose derived MSC secretome for the treatment of FCGST.

Methods:

Eight patients recruited prospectively with refractory FCGST, 3 to 12 months after partial or full mouth extraction, were included. All cats were free of systemic illness and had stopped treatment with immunomodulators at least 7 days before treatment. Cats visited on days 1, 30 and 90 for a clinical examination and treatment with 50 mg of injectable intralesional MSCs secretome. Monitoring of globulins, stomatitis disease activity index (SDAI) and histopathology, assessing the degree and quality of inflammation and mucosal damage, pre and post treatment were used for evaluation of therapeutical response.

Results:

SDAI decreased in 87% (7/8) of the cats on D90 compared to D1, while weight gain and lower globulinemia was observed in 62% (5/8) of the cats. Significant clinical and histopathological improvement was documented in 25% (2/8) of the cats, with ≥ 80% decrease of SDAI, weight gain and decrease in globulinemia. No adverse effects were observed.

Conclusions:

Addition of MSCs secretome to the treatment of cats after partial or full mouth extraction might lead to clinical and histopathological improvement in a subsection of cats.

Bibliographic Note

Information for this record is supplemented by the author(s) concerned.

Citation Format(s)

EFFECT OF XENOGENEIC MESENCHYMAL STEM CELL SECRETOME ON REFRACTORY FELINE CHRONIC GINGIVOSTOMATITIS. / Almendros, Angel; Moores, Claudia; Nekouei, Omid et al.
2023. 48th World Small Animal Veterinary Association Congress (WSAVA 2023) and 28th Federation of European Companion Animal Veterinary Associations (FECAVA) Eurocongress, Lisbon, Portugal.

Research output: Conference PapersRGC 33 - Other conference paperpeer-review