Effect of methionine deficiency on the apoptosis and cell cycle of kidney in broilers

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)228-236
Number of pages9
Journal / PublicationResearch in Veterinary Science
Volume135
Online published16 Oct 2019
Publication statusPublished - Mar 2021
Externally publishedYes

Abstract

Abundant evidence now supports the idea that methionine deficiency has negative effects on chicken healthy especially in the aspect of cell cycle regulation and apoptosis. But, lacking of knowledge is the evaluation on metabolic organs. To test the effect of methionine deficiency on the kidney, we assessed the apoptosis and the cell cycle of kidney induced by methionine deficiency by the methods of TdT-mediated dUTP Nick-End Labeling (TUNEL), flow cytometry (FCM), quantitative real-time PCR (qRT-PCR) and Enzyme-Linked ImmunoSorbent Assay (ELISA) of chickens for 42 days of age. Our results showed that the number of the apoptotic cells was increased (p

Research Area(s)

  • Methionine deficiency, Apoptosis, Cell cycle, Broilers