Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jinchao Zhang
  • Tianlan Zhang
  • Shanjin Xu
  • Kui Wang
  • Shifeng Yu

Detail(s)

Original languageEnglish
Pages (from-to)580-583
Journal / PublicationJournal of Rare Earths
Volume23
Issue number5
Publication statusPublished - Oct 2005

Abstract

The effect of lanthanum (III) (La3+) on cytosolic free calcium ([Ca2+]i) in isolated rabbit mature osteoclasts was studied with the employment of fluo-3/AM as an intracellular calcium-sensitive fluorescent probe by using a confocal laser scanning microscope. La3+ does not alter basal [Ca2+]; levels and cell spread area at the concentration of 1.00 × 10-8 mol·L-1. However, La3+ at higher concentrations (1.00 × l0-5 and 1.00 × 10-7 mol·L-1) decreases [Ca2+]i levels and cell spread area, and greater decreases are observed for the higher concentrations of La3+. Since [Ca2+]i affects cytoskeleton and the adhesion properties of osteoclasts, our results seem to suggest that La3+ inhibit bone resorption by decreasing [Ca2+]; in rabbit mature osteoclasts.

Research Area(s)

  • Cytosolic free calcium, Fluo-3/AM, Lanthanum (III), Osteoclasts, Rare earths

Citation Format(s)

Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts. / Zhang, Jinchao; Zhang, Tianlan; Xu, Shanjin; Wang, Kui; Yu, Shifeng; Yang, Mengsu.

In: Journal of Rare Earths, Vol. 23, No. 5, 10.2005, p. 580-583.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review