Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts

Jinchao Zhang; Tianlan Zhang; Shanjin Xu; Kui Wang; Shifeng Yu; Mengsu Yang

doi:10.1115/1.1897745

Author(s)

Jinchao Zhang
Tianlan Zhang
Shanjin Xu
Kui Wang
Shifeng Yu

Detail(s)

Original language	English
Pages (from-to)	580-583
Journal / Publication	Journal of Rare Earths
Volume	23
Issue number	5
Publication status	Published - Oct 2005

Link(s)

DOI	DOI https://doi.org/10.1115/1.1897745 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-30044431802&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(56fc3424-d7f7-4700-81a6-5f9f87156ed4).html

Abstract

The effect of lanthanum (III) (La³⁺) on cytosolic free calcium ([Ca²⁺]_i) in isolated rabbit mature osteoclasts was studied with the employment of fluo-3/AM as an intracellular calcium-sensitive fluorescent probe by using a confocal laser scanning microscope. La³⁺ does not alter basal [Ca²⁺]; levels and cell spread area at the concentration of 1.00 × 10^-8 mol·L^-1. However, La³⁺ at higher concentrations (1.00 × l0^-5 and 1.00 × 10^-7 mol·L^-1) decreases [Ca²⁺]_i levels and cell spread area, and greater decreases are observed for the higher concentrations of La³⁺. Since [Ca²⁺]_i affects cytoskeleton and the adhesion properties of osteoclasts, our results seem to suggest that La³⁺ inhibit bone resorption by decreasing [Ca²⁺]; in rabbit mature osteoclasts.

Research Area(s)

Cytosolic free calcium, Fluo-3/AM, Lanthanum (III), Osteoclasts, Rare earths

Citation Format(s)

[ RIS ] [ BibTeX ]

Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts. / Zhang, Jinchao; Zhang, Tianlan; Xu, Shanjin et al.
In: Journal of Rare Earths, Vol. 23, No. 5, 10.2005, p. 580-583.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Zhang, J, Zhang, T, Xu, S, Wang, K, Yu, S & Yang, M 2005, 'Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts', Journal of Rare Earths, vol. 23, no. 5, pp. 580-583. https://doi.org/10.1115/1.1897745

Zhang, J., Zhang, T., Xu, S., Wang, K., Yu, S., & Yang, M. (2005). Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts. Journal of Rare Earths, 23(5), 580-583. https://doi.org/10.1115/1.1897745

Zhang J, Zhang T, Xu S, Wang K, Yu S, Yang M. Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts. Journal of Rare Earths. 2005 Oct;23(5):580-583. doi: 10.1115/1.1897745

Zhang, Jinchao ; Zhang, Tianlan ; Xu, Shanjin et al. / Effect of lanthanum (III) on cytosolic free calcium in isolated rabbit mature osteoclasts. In: Journal of Rare Earths. 2005 ; Vol. 23, No. 5. pp. 580-583.