Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Wenkai Ren
  • Yulong Yin
  • Gang Liu
  • Xinglong Yu
  • Yinghui Li
  • Teijun Li
  • Guoyao Wu

Detail(s)

Original languageEnglish
Pages (from-to)2089-2094
Number of pages6
Journal / PublicationAmino Acids
Volume42
Issue number6
Online published27 May 2011
Publication statusPublished - Jun 2012
Externally publishedYes

Link(s)

Abstract

The objective of this study was to investigate whether supplemental dietary arginine increases reproductive performance in mice infected with porcine circovirus type2 (PCV2). A total of 50KM female mice were allotted randomly to the arginine group (0.6% arginine + gestation diet) and control group (1.22% alanine + gestation diet). All the mice began to mate after 14 days of treatment with our prepared feed and challenged with PCV2 at the dose of 100 TCID50 (50% tissue culture infection dose, TCID50) after 7 days of pregnancy. Abortion rate, litter number, litter birth weight, the daily weight gain in the first 7 days and survival rate in the first 2 weeks of the neonates were calculated. The serum progesterone, estrogen, nitric oxide and superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) on the 14th day of pregnancy were measured. Arginine supplementation decreased the abortion rate of pregnant mice and mortality of neonates caused by PCV2 infection. Further, litter number, litter birth weight and the daily weight gain of neonates increased in the arginine group compared to the control group. Arginine supplementation increased significantly the serum progesterone (P < 0.01) and nitric oxide levels (P < 0.05), but had little effect on the serum estrogen level. SOD activity and T-AOC in the arginine group were significantly higher (P < 0.01) than the control group. In conclusion, arginine supplementation partially reversed the reproductive failure in mice caused by PCV2 infection.

Research Area(s)

  • Arginine, Porcine circovirus, Progesterone, Nitric oxide

Citation Format(s)

Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection. / Ren, Wenkai; Yin, Yulong; Liu, Gang et al.
In: Amino Acids, Vol. 42, No. 6, 06.2012, p. 2089-2094.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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