ECoG Power Alterations Across Stages of Prolonged Transcorneal Electrical Stimulation in the Blind Mice

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review

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Detail(s)

Original languageEnglish
Title of host publication2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
PublisherIEEE
Pages5784-5787
ISBN (Electronic)978-1-7281-1179-7
ISBN (Print)978-1-7281-1180-3
Publication statusPublished - 2021

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)2375-7477
ISSN (Electronic)2694-0604

Conference

Title43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2021)
LocationVirtual
Period1 - 5 November 2021

Abstract

Transcorneal electrical stimulation (TES) is a noninvasive approach for activating the retina and its downstream components through the application of electric current on the cornea. Although previous studies have demonstrated the clinical relevance of TES for modulating neurons with improvements in visual evoked potentials (VEPs) and electroretinograms (ERGs), there are still huge gaps in knowledge of its effect on the brain structures. To determine the short-term impact as well as the aftereffects of TES on neural oscillatory power in retinal degeneration mice, we performed electrocorticography (ECoG) recording in the prefrontal and primary visual cortices at different stages of prolonged TES [transient stage, following prolonged stimulation (post-stimulation stage 1) and long after the end of the retinal stimulation (post-stimulation stage 2)]) under varying stimulation current amplitudes (400 µA, 500 µA and 600 µA). The results revealed asymmetric differences between short-term and long-term pTES under different stimulation current amplitudes. Specifically, in post-stimulation stage 1 we observed significant increase in ECoG power of theta, alpha and beta oscillations respectively compared with baseline pre-stimulation results. These effects were dependent on the stimulation current amplitude and stimulation stage. Transient TES was not sufficient to cause significant changes in the ECoG power of all accessed oscillations except in medium, high and ultra-gamma oscillations which significantly decreased in 400 µA and 500 µA stimulation groups respectively compared with pre-stimulation results. Regarding long-term stimulation, the increase in ECoG power of theta, alpha and beta oscillations observed in post-stimulation stage 1 was significantly maintained in post-stimulation stage 2.

Citation Format(s)

ECoG Power Alterations Across Stages of Prolonged Transcorneal Electrical Stimulation in the Blind Mice. / Agadagba , Stephen K.; Eldaly, Abdelrahman B.M.; Chan, Leanne L.H.

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2021. p. 5784-5787 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review