Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 9543-9546 |
| Journal / Publication | Chemical Communications |
| Volume | 51 |
| Issue number | 46 |
| Online published | 20 Apr 2015 |
| Publication status | Published - 11 Jun 2015 |
| Externally published | Yes |
Link(s)
Abstract
We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys221 residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.
Citation Format(s)
Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1). / Chiou, Jiachi; Wan, Shengbiao; Chan, Kin-Fai; So, Pui-Kin; He, Dandan; Chan, Edward Wai-Chi; Chan, Tak-Hang; Wong, Kwok-Yin; Tao, Jiang; Chen, Sheng.
In: Chemical Communications, Vol. 51, No. 46, 11.06.2015, p. 9543-9546.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
