Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jiachi Chiou
  • Shengbiao Wan
  • Kin-Fai Chan
  • Pui-Kin So
  • Dandan He
  • Edward Wai-Chi Chan
  • Tak-Hang Chan
  • Kwok-Yin Wong
  • Jiang Tao

Detail(s)

Original languageEnglish
Pages (from-to)9543-9546
Journal / PublicationChemical Communications
Volume51
Issue number46
Online published20 Apr 2015
Publication statusPublished - 11 Jun 2015
Externally publishedYes

Abstract

We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys221 residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.

Citation Format(s)

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1). / Chiou, Jiachi; Wan, Shengbiao; Chan, Kin-Fai; So, Pui-Kin; He, Dandan; Chan, Edward Wai-Chi; Chan, Tak-Hang; Wong, Kwok-Yin; Tao, Jiang; Chen, Sheng.

In: Chemical Communications, Vol. 51, No. 46, 11.06.2015, p. 9543-9546.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review