EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Lijun Jiang; Yin-Lai Lui; Hongguang Li; Chi-Fai Chan; Rongfeng Lan; Wai-Lun Chan; Terrence Chi-Kong Lau; George Sai-Wah Tsao; Nak-Ki Mak; Ka-Leung Wong

doi:10.1039/c4cc01589d

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Lijun Jiang
, Yin-Lai Lui
, Hongguang Li
, Chi-Fai Chan
, Rongfeng Lan
, Wai-Lun Chan
, Terrence Chi-Kong Lau
, George Sai-Wah Tsao
, Nak-Ki Mak
, Ka-Leung Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

24 Citations (Scopus)

Abstract

An EBNA1-specific small molecule (JLP₂) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP₂ may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells. This journal is © the Partner Organisations 2014.

Original language	English
Pages (from-to)	6517-6519
Journal	Chemical Communications
Volume	50
Issue number	49
DOIs	https://doi.org/10.1039/c4cc01589d
Publication status	Published - 21 Jun 2014

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title = "EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells",

abstract = "An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells. This journal is {\textcopyright} the Partner Organisations 2014.",

author = "Lijun Jiang and Yin-Lai Lui and Hongguang Li and Chi-Fai Chan and Rongfeng Lan and Wai-Lun Chan and Lau, \{Terrence Chi-Kong\} and Tsao, \{George Sai-Wah\} and Nak-Ki Mak and Ka-Leung Wong",

year = "2014",

month = jun,

day = "21",

doi = "10.1039/c4cc01589d",

language = "English",

volume = "50",

pages = "6517--6519",

journal = "Chemical Communications",

issn = "0009-241X",

publisher = "Royal Society of Chemistry",

number = "49",

}

TY - JOUR

T1 - EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

AU - Jiang, Lijun

AU - Lui, Yin-Lai

AU - Li, Hongguang

AU - Chan, Chi-Fai

AU - Lan, Rongfeng

AU - Chan, Wai-Lun

AU - Lau, Terrence Chi-Kong

AU - Tsao, George Sai-Wah

AU - Mak, Nak-Ki

AU - Wong, Ka-Leung

PY - 2014/6/21

Y1 - 2014/6/21

N2 - An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells. This journal is © the Partner Organisations 2014.

AB - An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells. This journal is © the Partner Organisations 2014.

UR - https://www.scopus.com/pages/publications/84901374691

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84901374691&origin=recordpage

U2 - 10.1039/c4cc01589d

DO - 10.1039/c4cc01589d

M3 - RGC 21 - Publication in refereed journal

C2 - 24821080

SN - 0009-241X

VL - 50

SP - 6517

EP - 6519

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Abstract

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