Early developmental toxicity of saxitoxin on medaka (Oryzias melastigma) embryos

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

15 Scopus Citations
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Author(s)

  • Li Tian
  • Jinping Cheng
  • Xueping Chen
  • Yim Ling Mak
  • Paul Kwan Sing Lam
  • Mingfu Wang

Detail(s)

Original languageEnglish
Pages (from-to)16-25
Journal / PublicationToxicon
Volume77
Publication statusPublished - 2014

Abstract

Saxitoxin (STX) is the most potent paralytic shellfish poisoning toxin in crustaceans and molluscs, and is known to cause intoxication to humans and marine animals due to its neurotoxicity. However, the extent of its early developmental toxicity to marine species remains unknown. In this study, we examined the early developmental toxicity of STX using marine medaka (Oryzias melastigma) embryos as model. The medaka embryos were exposed to STX for four days, from the early blastula stage onwards, and this exposure period covered the main developmental stage of the central nervous system and somites. After exposure, the treated medaka eleutheroembryos at 15 day post fertilization exhibited abnormal growth with longer body length and relatively smaller yolk sac size. High cell proliferation, neuron development, and metabolism were confirmed using whole-mount immunostaining and two-dimensional electrophoresis. In summary, STX disturbed the normal growth of medaka embryos probably by affecting the metabolic rate in the exposed medaka embryos. © 2013 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Developmental toxicity, Endocrine disruptor, Paralytic shellfish poisoning, Proteomics, Saxitoxin

Citation Format(s)

Early developmental toxicity of saxitoxin on medaka (Oryzias melastigma) embryos. / Tian, Li; Cheng, Jinping; Chen, Xueping; Cheng, Shuk Han; Mak, Yim Ling; Lam, Paul Kwan Sing; Chan, Leo Lai; Wang, Mingfu.

In: Toxicon, Vol. 77, 2014, p. 16-25.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review