Dynamics of longitudinal dentate gyrus axons associated with seizure

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)2273-2281
Number of pages21
Journal / PublicationJournal of Physiology
Volume599
Issue number8
Online published6 Mar 2021
Publication statusPublished - 15 Apr 2021

Abstract

The hippocampus network has captured the attention of neuroscientists as a model for understanding cognition and behaviour. Previously, we have identified interlamellar, namely longitudinal, axons between CA1 pyramidal neurons analogous to recurrent connections between CA3 pyramidal neurons. Currently it is unknown whether longitudinal axons of DG granule neurons are present and how they are associated with the behavioural symptoms of seizure. We found longitudinal axons projections from DG granule cells extending to neighbouring DG granule cell layers. These DG-DG axons have more numerous varicosities and are thinner than the DG-CA3 axons, suggesting heavy synaptic formation along a longitudinal axis. Furthermore, the size of varicosities in the DG-DG but not DG-CA3 axons is regulated by seizures as measured behaviourally. The results suggest that the dynamics of longitudinal DG axons is a symptomatic marker of DG-related brain diseases.

Research Area(s)

  • DG granule cells, epilepsy, hippocampus circuit, longitudinal axons, varicosity

Citation Format(s)

Dynamics of longitudinal dentate gyrus axons associated with seizure. / Choi, Gona; Kang, Hyeri ; Chu, Wenkei; Yang, Sunggu; Yang, Sungchil.

In: Journal of Physiology, Vol. 599, No. 8, 15.04.2021, p. 2273-2281.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review