Dynamics analysis and motion planning for automated cell transportation with optical tweezers

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Original languageEnglish
Article number6142108
Pages (from-to)706-713
Journal / PublicationIEEE/ASME Transactions on Mechatronics
Issue number2
Publication statusPublished - Apr 2013


With such advantages as nonphysical cell contact and a relatively high efficiency, the application of optical tweezers for the manipulation of biological cells has received increasing attention in recent years. The use of optical tweezers to transfer cells to user-defined goal positions is useful in many biomedical applications. In this paper, we investigate how to automatically transport biological cells using robotically controlled optical tweezers. We characterize the forces applied to a trapped cell by a dynamic viscous drag forcemethod, which provides us insight into information on optimal motion parameters. To prevent the cell from escaping the optical trap and to ensure high efficiency in cell movement, a proportional-integral (PI) scheme, designed based on calibrated dynamic parameters, is used to determine the ideal movement velocity of the cell. The PI scheme utilizes a feedback of the actual cell displacement from the laser focus. Finally, a modified A* algorithm is adopted for path planning during automated cell transportation. Experiments are finally performed to verify the proposed approach. © 2012 IEEE.

Research Area(s)

  • Cell transportation, Force characterization, Motion plan, Optical tweezers