Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia
Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
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| Publication status | Published - May 2022 |
Conference
| Title | 2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting |
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| Location | Hybrid |
| Place | United Kingdom |
| City | London |
| Period | 7 - 12 May 2022 |
Link(s)
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(783db8fe-744c-4581-8fa6-f9e53b9eede5).html |
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Abstract
Dynamic glucose enhanced (DGE) MRI can detect glucose-related events in the brain, however, the influence of oxygen levels on DGE signal remains unknown. Here, we investigated the DGE signal changes under normoxia and hyperoxia on mouse brain, using on-resonance variable delay multi-pulse (onVDMP) MRI. Significantly higher signal change under normoxia than that under hyperoxia was observed in parenchyma but not in cerebrospinal fluid (CSF). Without glucose infusion, a signal increment of about 3% was found in both parenchyma and CSF from hyperoxia to normoxia, interpreted as related to BOLD effect. These data provide insight into the origin of glucoCEST contrast.
Citation Format(s)
Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia. / Huang, Jianpan; Chen, Zilin; van Zijl, Peter C. M. et al.
2022. Paper presented at 2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, London, United Kingdom.
2022. Paper presented at 2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, London, United Kingdom.
Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review
