Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia

Jianpan Huang; Zilin Chen; Peter C. M. van Zijl; Lok Hin Law; Rohith Saai Pemmasani Prabakaran; Se Weon Park; Jiadi Xu; Kannie W. Y. Chan

Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia

Jianpan Huang (Co-first Author)
, Zilin Chen (Co-first Author)
, Peter C. M. van Zijl
, Lok Hin Law
, Rohith Saai Pemmasani Prabakaran
, Se Weon Park
, Jiadi Xu
, Kannie W. Y. Chan^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review

Abstract

Dynamic glucose enhanced (DGE) MRI can detect glucose-related events in the brain, however, the influence of oxygen levels on DGE signal remains unknown. Here, we investigated the DGE signal changes under normoxia and hyperoxia on mouse brain, using on-resonance variable delay multi-pulse (onVDMP) MRI. Significantly higher signal change under normoxia than that under hyperoxia was observed in parenchyma but not in cerebrospinal fluid (CSF). Without glucose infusion, a signal increment of about 3% was found in both parenchyma and CSF from hyperoxia to normoxia, interpreted as related to BOLD effect. These data provide insight into the origin of glucoCEST contrast.

Original language	English
Publication status	Published - May 2022
Event	2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting - Hybrid, London, United Kingdom Duration: 7 May 2022 → 12 May 2022 https://www.ismrm.org/22m/

Conference

Conference	2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting
Place	United Kingdom
City	London
Period	7/05/22 → 12/05/22
Internet address	https://www.ismrm.org/22m/

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@conference{783db8fe744c45818fa6f9e53b9eede5,

title = "Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia",

abstract = "Dynamic glucose enhanced (DGE) MRI can detect glucose-related events in the brain, however, the influence of oxygen levels on DGE signal remains unknown. Here, we investigated the DGE signal changes under normoxia and hyperoxia on mouse brain, using on-resonance variable delay multi-pulse (onVDMP) MRI. Significantly higher signal change under normoxia than that under hyperoxia was observed in parenchyma but not in cerebrospinal fluid (CSF). Without glucose infusion, a signal increment of about 3\% was found in both parenchyma and CSF from hyperoxia to normoxia, interpreted as related to BOLD effect. These data provide insight into the origin of glucoCEST contrast.",

author = "Jianpan Huang and Zilin Chen and \{van Zijl\}, \{Peter C. M.\} and Law, \{Lok Hin\} and \{Pemmasani Prabakaran\}, \{Rohith Saai\} and Park, \{Se Weon\} and Jiadi Xu and Chan, \{Kannie W. Y.\}",

year = "2022",

month = may,

language = "English",

note = "2022 Joint Annual Meeting ISMRM-ESMRMB \& ISMRT 31st Annual Meeting ; Conference date: 07-05-2022 Through 12-05-2022",

url = "https://www.ismrm.org/22m/",

}

Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia. / Huang, Jianpan (Co-first Author); Chen, Zilin (Co-first Author); van Zijl, Peter C. M. et al.
2022. Paper presented at 2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, London, United Kingdom.

Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review

TY - CONF

T1 - Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia

AU - Huang, Jianpan

AU - Chen, Zilin

AU - van Zijl, Peter C. M.

AU - Law, Lok Hin

AU - Pemmasani Prabakaran, Rohith Saai

AU - Park, Se Weon

AU - Xu, Jiadi

AU - Chan, Kannie W. Y.

PY - 2022/5

Y1 - 2022/5

N2 - Dynamic glucose enhanced (DGE) MRI can detect glucose-related events in the brain, however, the influence of oxygen levels on DGE signal remains unknown. Here, we investigated the DGE signal changes under normoxia and hyperoxia on mouse brain, using on-resonance variable delay multi-pulse (onVDMP) MRI. Significantly higher signal change under normoxia than that under hyperoxia was observed in parenchyma but not in cerebrospinal fluid (CSF). Without glucose infusion, a signal increment of about 3% was found in both parenchyma and CSF from hyperoxia to normoxia, interpreted as related to BOLD effect. These data provide insight into the origin of glucoCEST contrast.

AB - Dynamic glucose enhanced (DGE) MRI can detect glucose-related events in the brain, however, the influence of oxygen levels on DGE signal remains unknown. Here, we investigated the DGE signal changes under normoxia and hyperoxia on mouse brain, using on-resonance variable delay multi-pulse (onVDMP) MRI. Significantly higher signal change under normoxia than that under hyperoxia was observed in parenchyma but not in cerebrospinal fluid (CSF). Without glucose infusion, a signal increment of about 3% was found in both parenchyma and CSF from hyperoxia to normoxia, interpreted as related to BOLD effect. These data provide insight into the origin of glucoCEST contrast.

M3 - RGC 32 - Refereed conference paper (without host publication)

T2 - 2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting

Y2 - 7 May 2022 through 12 May 2022

ER -

Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia

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