Dynamic glucose enhanced (DGE) MRI at 3T detects alterations in glucose uptake and clearance in young and old Alzheimer’s mice

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)Abstractpeer-review

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Author(s)

  • Celia M. Dong
  • Gerald W. Y. Cheng
  • Kai-Hei Tse
  • Lin Chen
  • Ed X. Wu
  • Peter C. M. van Zijl
  • Jiadi Xu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Publication statusPublished - Aug 2020

Conference

TitleISMRM & SMRT Virtual Conference & Exhibition
Period8 - 14 August 2020

Abstract

On-resonance variable delay multiple pulse (onVDMP) CEST MRI was applied to detect dynamic D-glucose enhanced signal in brain parenchyma and CSF of 6- and 16-month old APP/PS1 AD mice. A significantly slower D-glucose clearance from CSF was observed in young AD mice compared to age-matched wild type (WT) mice. Moreover, a reduced D-glucose uptake was observed both in parenchyma and CSF of old APP/PS1 mice. D-glucose kinetics detected by onVDMP can be used to assess the alterations in D-glucose uptake and clearance in AD and in the course of AD progression at 3T, a clinical relevant MRI field.

Citation Format(s)

Dynamic glucose enhanced (DGE) MRI at 3T detects alterations in glucose uptake and clearance in young and old Alzheimer’s mice. / Huang, Jianpan; Han, Xiongqi; Dong, Celia M.; Cheng, Gerald W. Y.; Tse, Kai-Hei; Chen, Lin; Lai, Joseph H. C.; Wu, Ed X.; van Zijl, Peter C. M.; Xu, Jiadi; Chan, Kannie W. Y.

2020. Abstract from ISMRM & SMRT Virtual Conference & Exhibition, .

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)Abstractpeer-review