Dynamic control of cell migration using optical tweezers and microfluidic channel

Xue Gou; Xiaolin Wang; Hao Yang; Xiao Yan; Yong Wang; Tarek M. Fahmy; Dong Sun

doi:10.1109/NANO.2012.6321983

Dynamic control of cell migration using optical tweezers and microfluidic channel

Xue Gou, Xiaolin Wang, Hao Yang, Xiao Yan, Yong Wang, Tarek M. Fahmy, Dong Sun^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

2 Citations (Scopus)

Abstract

This paper presents the development of a single-cell motility assay method that allows the quantification of cell chemotaxis under complex hydrodynamic condition. The specially designed microparticles, which contain cytokines and chemokines, are trapped by the optical tweezers in motion while releasing the chemical to stimulate the cell polarization and migration. The morphology, localization, and migration speed of the cell are examined quantitatively under different shear stresses. Experiments of migrating leukemia cells led by two microparticles releasing SDF-1a are performed to demonstrate the effectiveness of the proposed approach. This method will provide a new opportunity to probe the mechanism of cell migration at molecular and nano-scale precision level, and help clinicians to develop new targeted therapies in nanomedicine. © 2012 IEEE.

Original language	English
Title of host publication	Proceedings of the IEEE Conference on Nanotechnology
DOIs	https://doi.org/10.1109/NANO.2012.6321983
Publication status	Published - 2012
Event	12th IEEE International Conference on Nanotechnology (IEEE NANO 2012) - International Convention Centre, Birmingham, United Kingdom Duration: 20 Aug 2012 → 23 Aug 2012

Publication series

Name
ISSN (Print)	1944-9399
ISSN (Electronic)	1944-9380

Conference

Conference	12th IEEE International Conference on Nanotechnology (IEEE NANO 2012)
Place	United Kingdom
City	Birmingham
Period	20/08/12 → 23/08/12

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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@inproceedings{df1eba1c63e642e2ac06bab2f8045d60,

title = "Dynamic control of cell migration using optical tweezers and microfluidic channel",

abstract = "This paper presents the development of a single-cell motility assay method that allows the quantification of cell chemotaxis under complex hydrodynamic condition. The specially designed microparticles, which contain cytokines and chemokines, are trapped by the optical tweezers in motion while releasing the chemical to stimulate the cell polarization and migration. The morphology, localization, and migration speed of the cell are examined quantitatively under different shear stresses. Experiments of migrating leukemia cells led by two microparticles releasing SDF-1a are performed to demonstrate the effectiveness of the proposed approach. This method will provide a new opportunity to probe the mechanism of cell migration at molecular and nano-scale precision level, and help clinicians to develop new targeted therapies in nanomedicine. {\textcopyright} 2012 IEEE.",

author = "Xue Gou and Xiaolin Wang and Hao Yang and Xiao Yan and Yong Wang and Fahmy, {Tarek M.} and Dong Sun",

year = "2012",

doi = "10.1109/NANO.2012.6321983",

language = "English",

isbn = "9781467321983",

booktitle = "Proceedings of the IEEE Conference on Nanotechnology",

note = "12th IEEE International Conference on Nanotechnology (IEEE NANO 2012) ; Conference date: 20-08-2012 Through 23-08-2012",

}

TY - GEN

T1 - Dynamic control of cell migration using optical tweezers and microfluidic channel

AU - Gou, Xue

AU - Wang, Xiaolin

AU - Yang, Hao

AU - Yan, Xiao

AU - Wang, Yong

AU - Fahmy, Tarek M.

AU - Sun, Dong

PY - 2012

Y1 - 2012

N2 - This paper presents the development of a single-cell motility assay method that allows the quantification of cell chemotaxis under complex hydrodynamic condition. The specially designed microparticles, which contain cytokines and chemokines, are trapped by the optical tweezers in motion while releasing the chemical to stimulate the cell polarization and migration. The morphology, localization, and migration speed of the cell are examined quantitatively under different shear stresses. Experiments of migrating leukemia cells led by two microparticles releasing SDF-1a are performed to demonstrate the effectiveness of the proposed approach. This method will provide a new opportunity to probe the mechanism of cell migration at molecular and nano-scale precision level, and help clinicians to develop new targeted therapies in nanomedicine. © 2012 IEEE.

AB - This paper presents the development of a single-cell motility assay method that allows the quantification of cell chemotaxis under complex hydrodynamic condition. The specially designed microparticles, which contain cytokines and chemokines, are trapped by the optical tweezers in motion while releasing the chemical to stimulate the cell polarization and migration. The morphology, localization, and migration speed of the cell are examined quantitatively under different shear stresses. Experiments of migrating leukemia cells led by two microparticles releasing SDF-1a are performed to demonstrate the effectiveness of the proposed approach. This method will provide a new opportunity to probe the mechanism of cell migration at molecular and nano-scale precision level, and help clinicians to develop new targeted therapies in nanomedicine. © 2012 IEEE.

UR - http://www.scopus.com/inward/record.url?scp=84869183835&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84869183835&origin=recordpage

U2 - 10.1109/NANO.2012.6321983

DO - 10.1109/NANO.2012.6321983

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781467321983

BT - Proceedings of the IEEE Conference on Nanotechnology

T2 - 12th IEEE International Conference on Nanotechnology (IEEE NANO 2012)

Y2 - 20 August 2012 through 23 August 2012

ER -

Dynamic control of cell migration using optical tweezers and microfluidic channel

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