Dual-Stimuli-Responsive, Polymer-Microsphere-Encapsulated CuS Nanoparticles for Magnetic Resonance Imaging Guided Synergistic Chemo-Photothermal Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

22 Scopus Citations
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Author(s)

  • Zhe Yang
  • Wei Zhu
  • Zhilan Ye
  • Yiming Yu
  • Zushun Xu
  • Jinghua Ren
  • Penghui Li

Detail(s)

Original languageEnglish
Pages (from-to)1690-1701
Journal / PublicationACS Biomaterial Science and Engineering
Volume3
Issue number8
Online published26 Jun 2017
Publication statusPublished - 14 Aug 2017
Externally publishedYes

Abstract

Integrating biomedical imaging and multimodal therapies into one platform for enhanced anticancer efficacy is of great significance. Herein, a core/shell structured nanotheranostic (CuS@copolymer) for magnetic resonance imaging (MRI)-guided chemo-photothermal therapy was simply prepared via emulsifier-free emulsion polymerization with the full participation of hydrophilic CuS NPs, styrene (St), N-isopropylacrylamide (NIPAm), methacrylic acid (MAA), and polymerizable rare earth complex (Gd(AA)3phen). The synthesized multifunctional microspheres with excellent biocompatibility exhibited high loading capacity (15.3 wt %) for DOX·HCl and excellent drug release under low pH and high temperature. The photosensitive CuS cores which can simultaneously efficiently absorb near-infrared (NIR) light and convert NIR light to fatal heat, leading to a synergistic therapeutic effect combined photothermal therapy (PTT) with chemotherapy. Moreover, the temperature sensitive copolymer attached onto the CuS nanoparticles was able to be productively infected by the thermal effect and give rise to a highly controllable DOX release. Furthermore, the CuS@copolymer/DOX showed an enhanced therapeutic efficacy against 4T1 cells than separate photothermal therapy or chemotherapy. Additionally, the drug delivery procedure could be visualized by in vivo MR images and the longitudinal relaxivity (r1) was calculated to be 10.72 mM–1 s–1. These results suggest the CuS@copolymer microspheres highly attractive candidates for biomedical applications.

Research Area(s)

  • MRI, stimuli-responsive, CuS nanoparticles, NIR, synergistic therapeutic

Citation Format(s)

Dual-Stimuli-Responsive, Polymer-Microsphere-Encapsulated CuS Nanoparticles for Magnetic Resonance Imaging Guided Synergistic Chemo-Photothermal Therapy. / Zhang, Li; Yang, Zhe; Zhu, Wei; Ye, Zhilan; Yu, Yiming; Xu, Zushun; Ren, Jinghua; Li, Penghui.

In: ACS Biomaterial Science and Engineering, Vol. 3, No. 8, 14.08.2017, p. 1690-1701.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal