Dual-function, cationic peptide-coated nanodiamond system : Facilitating gene delivery to the nucleus for enhanced disease therapy

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)Posterpeer-review

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Detail(s)

Original languageEnglish
Publication statusPublished - May 2018

Conference

Title2nd International Conference and Exhibition on Nanomedicine and Drug Delivery
PlaceJapan
CityTokyo
Period21 - 23 May 2018

Abstract

Nano-diamond becomes a promising candidate among the carbon-based nanomaterials in the recent decades. With the superior thermal stability and chemical inertness, excellent cellular uptake, innate biocompatibility, low cytotoxicity and non-photobleaching fluorescent property, they can be functionalized as a therapeutic agent or diagnostic tool through the chemical modifications. We demonstrate the use of nanodiamonds as a platform for effective delivery of biomolecule with nucleus targeting property. With the peptide modified surface, it enables nanodiamonds to bind with the negative charged nucleic acid via electrostatic force. Antisense oligonucleotide 4625 is applied as an example to be transported, the suppression of Bcl-2 and Bcl-xL anti-apoptotic genes and triggering of apoptosis in breast carcinoma MCF-7 indicate the enhanced drug delivery efficiency. Therefore, nanodiamonds are promising nanocarriers to enhance the cellular delivery of certain biomolecules.

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Citation Format(s)

Dual-function, cationic peptide-coated nanodiamond system : Facilitating gene delivery to the nucleus for enhanced disease therapy. / Leung, Hoi Man; Lo, Pik Kwan .

2018. Poster session presented at 2nd International Conference and Exhibition on Nanomedicine and Drug Delivery, Tokyo, Japan.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)Posterpeer-review